Idiopathic pulmonary fibrosis (IPF) is a progressive fibrotic lung disease with an appalling
prognosis. The failure of anti-inflammatory therapies coupled with the observation that …

Transforming growth factor-β (TGFβ) plays a central role in a number of developmental and
pathological processes. There are 3 isoforms of TGFβ (1–3) and all are sequestered in the …

In December 2019, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) emerged,
causing the coronavirus disease 2019 (COVID-19) pandemic. SARS-CoV, the agent …

We further propose that this approach should inhibit fibrosis independent of cell type or the
signalling cascade that is activating these cells. We are hopeful that the next 20 years will …

Acute exacerbation of idiopathic pulmonary fibrosis has been defined as an acute, clinically
significant, respiratory deterioration of unidentifiable cause. The objective of this …

The views and recommendations made in this document do not represent the official position
of any publisher or professional medical society. This document has not been endorsed by …

Lung fibrosis can affect the parenchyma and the airways, classically giving rise to idiopathic
pulmonary fibrosis (IPF) in the parenchyma or airway remodeling in asthma and chronic …

Activation of latent transforming growth factor β (TGF-β) by αvβ6 integrin is critical in the
pathogenesis of lung injury and fibrosis. We have previously demonstrated that the stimulation of …

Rationale: Recent findings suggesting transforming growth factor (TGF)-β 1 activation by
mechanical stimuli in vitro raised the question of whether this phenomenon was relevant in vivo …

Background There is accumulating evidence for an overly activated immune response in
severe COVID-19, with several studies exploring the therapeutic role of immunomodulation. …