Background In 2010, overweight and obesity were estimated to cause 3·4 million deaths, 3·9%
of years of life lost, and 3·8% of disability-adjusted life-years (DALYs) worldwide. The rise …

Background The Dietary Approaches to Stop Hypertension (DASH) diet has been shown to
lower blood pressure, but little is known about its long-term effect on cardiovascular end …

Brain accumulation of the amyloid-β (Aβ) peptide is believed to be the initial event in the
Alzheimer disease (AD) process. Aβ accumulation begins 15–20 years before clinical …

Background The number of individuals living with dementia is increasing, negatively affecting
families, communities, and health-care systems around the world. A successful response …

Background Neurological disorders are now the leading source of disability globally, and
ageing is increasing the burden of neurodegenerative disorders, including Parkinson's disease…

Amyotrophic lateral sclerosis (ALS), also known as motor neuron disease, is characterized
by the degeneration of both upper and lower motor neurons, which leads to muscle …

Background Neurological disorders are increasingly recognised as major causes of death
and disability worldwide. The aim of this analysis from the Global Burden of Diseases, Injuries…

Background Comparable data on the global and country-specific burden of neurological
disorders and their trends are crucial for health-care planning and resource allocation. The …

Worldwide, about 65 million people are estimated to have epilepsy. Epidemiologic studies
are necessary to define the full public health burden of epilepsy; to set public health and …

We have performed a systematic review to summarize current knowledge concerning factors
related to survival in ALS and to evaluate the implications of these data for clinical trials …