Appropriate isolation methods are essential for unravelling the relative contribution of
extracellular vesicles (EVs) and the EV-free secretome to homeostasis and disease. We …

ISARIC aims to reach a global consensus behind collection of harmonised clinical data linked
with biological sampling protocols that are of value to anyone facing future outbreaks of …

Background Lower respiratory tract infection (LRTI) is the third leading cause of death
worldwide and the first leading cause of death in low‐income countries. Community‐acquired …

In the respiratory tract, viruses and bacteria can interact on multiple levels. It is well known
that respiratory viruses, particularly influenza viruses, increase the susceptibility to secondary …

Extracellular vesicles (EVs), including microvesicles and exosomes, are emerging as
important regulators of homeostasis and pathophysiology. During pro-inflammatory and pro-…

Introduction Airway epithelial cells have been described to release extracellular vesicles (EVs)
with pathological properties when exposed to cigarette smoke extract (CSE). As CSE …

Background: Disturbances of intestinal integrity, manifested by increased gastro-intestinal (GI)
permeability, have been found in chronic obstructive pulmonary disease (COPD) patients …

Background Remodelling in COPD has at least two dimensions: small airway wall thickening
and destruction of alveolar walls. Recent studies indicate that there is some similarity …

Extracellular vesicles (EV) are secreted signaling entities that enhance various pathological
processes when released in response to cellular stresses. Respiratory exposures such as …

Airway epithelial cells secrete extracellular vesicles (EVs) under basal conditions and when
exposed to cigarette smoke extract (CSE). Getting insights into the composition of these EVs …