Features of chronic asthma include airway hyperresponsiveness, inflammatory infiltrates,
and structural changes in the airways, termed remodeling. The contribution of eosinophils, …

Airway inflammation and remodeling are important pathophysiologic features of chronic
asthma. Previously, we have developed a mouse model of prolonged allergen challenge which …

Asthma is one of the most common respiratory disease that affects both children and adults
worldwide, with diverse phenotypes and underlying pathogenetic mechanisms poorly …

Osteopontin (Opn) is important for T helper type 1 (T H 1) immunity and autoimmunity.
However, the role of this cytokine in T H 2-mediated allergic disease as well as its effects on …

Objective. Many studies have shown that the microanatomic organization of infiltrating
leukocytes in the salivary gland lesions of patients with Sjögren’s syndrome (SS) resembles the …

More than thirty years ago functions of vitamin D other than its beneficial effects on calcium
homeostasis and bone metabolism have been identified, mainly in relation to its …

Approximately 90% of alpha-synuclein (α-Synuclein) deposited in Lewy bodies is
phosphorylated at serine 129 suggesting that the accumulation of phosphorylated α-Synuclein is …

The chemokine receptor CXCR3 is predominantly expressed on T lymphocytes, and its
agonists CXCL9, CXCL10 and CXCL11 are IFN‐γ‐inducible chemokines that promote Th1 …

Regulatory B cells (Bregs) play a critical role in the control of autoimmunity and inflammation.
IL-10 production is the hallmark for the identification of Bregs. However, the molecular …

The TGF-β superfamily of cytokines plays pivotal roles in the regulation of immune responses
protecting against or contributing to diseases, such as, allergy, autoimmunity and cancer. …