High-dose vitamin D3 during intensive-phase antimicrobial treatment of pulmonary tuberculosis: a double-blind randomised controlled trial
…, Y Hanifa, K Islam, AP Claxton, GE Packe… - The Lancet, 2011 - thelancet.com
Background Vitamin D was used to treat tuberculosis in the pre-antibiotic era, and its
metabolites induce antimycobacterial immunity in vitro. Clinical trials investigating the effect of …
metabolites induce antimycobacterial immunity in vitro. Clinical trials investigating the effect of …
A single dose of vitamin D enhances immunity to mycobacteria
…, B Kampmann, BM Hall, GE Packe… - American journal of …, 2007 - atsjournals.org
Rationale: Vitamin D was used to treat tuberculosis (TB) in the preantibiotic era. Prospective
studies to evaluate the effect of vitamin D supplementation on antimycobacterial immunity …
studies to evaluate the effect of vitamin D supplementation on antimycobacterial immunity …
[HTML][HTML] Neutrophil-mediated innate immune resistance to mycobacteria
…, BM Hall, N Nawroly, GE Packe… - The Journal of …, 2007 - Am Soc Clin Investig
Neutrophils contain antimicrobial peptides with antituberculous activity, but their contribution
to immune resistance to tuberculosis (TB) infection has not been previously investigated to …
to immune resistance to tuberculosis (TB) infection has not been previously investigated to …
Vitamin D accelerates resolution of inflammatory responses during tuberculosis treatment
…, GH Bothamley, GE Packe… - Proceedings of the …, 2012 - National Acad Sciences
Calcidiol, the major circulating metabolite of vitamin D, supports induction of pleiotropic
antimicrobial responses in vitro. Vitamin D supplementation elevates circulating calcidiol …
antimicrobial responses in vitro. Vitamin D supplementation elevates circulating calcidiol …
Neutrophilia independently predicts death in tuberculosis
DM Lowe, AK Bandara, GE Packe… - European …, 2013 - Eur Respiratory Soc
1 Falzon D, Jaramillo E, Schunemann HJ, et al. WHO guidelines for the programmatic
management of drug-resistant tuberculosis: 2011 update. Eur Respir J 2011; 38: 516–528. 2 …
management of drug-resistant tuberculosis: 2011 update. Eur Respir J 2011; 38: 516–528. 2 …
[HTML][HTML] Ethnic variation in inflammatory profile in tuberculosis
…, GH Bothamley, AP Claxton, GE Packe… - PLoS …, 2013 - journals.plos.org
Distinct phylogenetic lineages of Mycobacterium tuberculosis (MTB) cause disease in
patients of particular genetic ancestry, and elicit different patterns of cytokine and chemokine …
patients of particular genetic ancestry, and elicit different patterns of cytokine and chemokine …
Influences on hospital admission for asthma in south Asian and white adults: qualitative interview study
…, M Gantley, G Feder, S Hillier, J Goddard, G Packe - Bmj, 2001 - bmj.com
Objective: To explore reasons for increased risk of hospital admission among south Asian
patients with asthma. Design: Qualitative interview study using modified critical incident …
patients with asthma. Design: Qualitative interview study using modified critical incident …
Tuberculosis: a missed opportunity for early diagnosis at the front line?
TS Lad, GE Packe - Emergency Medicine Journal, 2014 - emj.bmj.com
Introduction The incidence of tuberculosis (TB) has increased over the last two decades.
Many patients with TB preferentially access healthcare via the emergency department (ED) …
Many patients with TB preferentially access healthcare via the emergency department (ED) …
Is porphyria cutanea tarda a risk factor in the development of hepatocellular carcinoma? A case report and review of the literature
GE Packe, CWF Clarke - Oncology, 1985 - karger.com
A patient with alcoholic liver cirrhosis, diabetes mellitus and porphyria cutanea tarda (PCT)
is described, who subsequently died of hepatocellular carcinoma. The literature relating PCT …
is described, who subsequently died of hepatocellular carcinoma. The literature relating PCT …
Improved vitamin D status despite allocation to placebo in a tuberculosis treatment trial: Contamination bias?
AR Martineau, CJ Griffiths, GE Packe - American journal of …, 2009 - atsjournals.org
In their article (1), Dr. Wejse and colleagues reported the finding that patients with tuberculosis
(TB) who were allocated to placebo in a treatment trial experienced a rise in serum 25-…
(TB) who were allocated to placebo in a treatment trial experienced a rise in serum 25-…