Angiotensin converting enzyme insertion/deletion polymorphism is associated with susceptibility and outcome in acute respiratory distress syndrome
…, SE Humphries, MR Hill, GJ Laurent - American journal of …, 2002 - atsjournals.org
Acute respiratory distress syndrome (ARDS) is an often fatal condition for which a genetic
predisposition is postulated, although no specific genes have been identified to date. …
predisposition is postulated, although no specific genes have been identified to date. …
Mechanisms of tissue repair: from wound healing to fibrosis
…, JE Bishop, G McGrouther, GJ Laurent - The international journal …, 1997 - Elsevier
To set the scene for this Directed Issue on Mechanisms of Tissue Repair of The International
Journal of Biochemistry and Cell Biology, this introductory overview briefly describes the …
Journal of Biochemistry and Cell Biology, this introductory overview briefly describes the …
A rapid and convenient assay for counting cells cultured in microwell plates: application for assessment of growth factors
…, JE Bishop, PJ Cole, GJ Laurent - Journal of cell …, 1989 - journals.biologists.com
… Cole, Geoffrey J. Laurent; A rapid and convenient assay for counting cells cultured in microwell
plates: Application for assessment of growth factors. J Cell Sci 1 March 1989; 92 (3): 513–…
plates: Application for assessment of growth factors. J Cell Sci 1 March 1989; 92 (3): 513–…
Common promoter variant in cyclooxygenase-2 represses gene expression: evidence of role in acute-phase inflammatory response
…, RP Marshall, SE Humphries, GJ Laurent - … , and vascular biology, 2002 - Am Heart Assoc
Objective— Cyclooxygenase (COX)-2 is a key regulatory enzyme in the synthesis of
prostanoids associated with trauma and inflammation. We investigated the COX-2 gene for …
prostanoids associated with trauma and inflammation. We investigated the COX-2 gene for …
Pulmonary fibrosis: searching for model answers
Substantial challenges remain in our understanding of fibrotic lung diseases. Nowhere is this
more true than in the elucidation and verification of the pathogenetic basis upon which they …
more true than in the elucidation and verification of the pathogenetic basis upon which they …
Mast cell tryptase stimulates human lung fibroblast proliferation via protease-activated receptor-2
…, MD Hollenberg, S Sanjar, GJ Laurent… - … of Physiology-Lung …, 2000 - journals.physiology.org
Mast cells play a potentially important role in fibroproliferative diseases, releasing mediators
including tryptase that are capable of stimulating fibroblast proliferation and procollagen …
including tryptase that are capable of stimulating fibroblast proliferation and procollagen …
Fibroproliferation occurs early in the acute respiratory distress syndrome and impacts on outcome
…, N Goldsack, RJ McANULTY, GJ Laurent - American journal of …, 2000 - atsjournals.org
The fibroproliferative phase of acute respiratory distress syndrome (ARDS) has traditionally
been regarded as a late event but recent studies that suggest increased lung collagen …
been regarded as a late event but recent studies that suggest increased lung collagen …
Angiotensin II and the fibroproliferative response to acute lung injury
…, T Unger, RJ McAnulty, GJ Laurent - … of Physiology-Lung …, 2004 - journals.physiology.org
Angiotensin II (ANG II), generated by activation of local renin-angiotensin systems, is believed
to play an important role in tissue repair and remodeling, in part via transforming growth …
to play an important role in tissue repair and remodeling, in part via transforming growth …
[HTML][HTML] Increased local expression of coagulation factor X contributes to the fibrotic response in human and murine lung injury
…, AG Nicholson, JD Moffatt, GJ Laurent… - The Journal of …, 2009 - Am Soc Clin Investig
Uncontrolled activation of the coagulation cascade contributes to the pathophysiology of
several conditions, including acute and chronic lung diseases. Coagulation zymogens are …
several conditions, including acute and chronic lung diseases. Coagulation zymogens are …
[HTML][HTML] Ligation of protease-activated receptor 1 enhances αv β6 integrin–dependent TGF-β activation and promotes acute lung injury
…, CJ Scotton, E Camerer, GJ Laurent… - The Journal of …, 2006 - Am Soc Clin Investig
Activation of latent TGF-β by the α v β 6 integrin is a critical step in the development of acute
lung injury. However, the mechanism by which α v β 6 -mediated TGF-β activation is …
lung injury. However, the mechanism by which α v β 6 -mediated TGF-β activation is …