Angiotensin converting enzyme insertion/deletion polymorphism is associated with susceptibility and outcome in acute respiratory distress syndrome

…, SE Humphries, MR Hill, GJ Laurent - American journal of …, 2002 - atsjournals.org
Acute respiratory distress syndrome (ARDS) is an often fatal condition for which a genetic
predisposition is postulated, although no specific genes have been identified to date. …

Mechanisms of tissue repair: from wound healing to fibrosis

…, JE Bishop, G McGrouther, GJ Laurent - The international journal …, 1997 - Elsevier
To set the scene for this Directed Issue on Mechanisms of Tissue Repair of The International
Journal of Biochemistry and Cell Biology, this introductory overview briefly describes the …

A rapid and convenient assay for counting cells cultured in microwell plates: application for assessment of growth factors

…, JE Bishop, PJ Cole, GJ Laurent - Journal of cell …, 1989 - journals.biologists.com
… Cole, Geoffrey J. Laurent; A rapid and convenient assay for counting cells cultured in microwell
plates: Application for assessment of growth factors. J Cell Sci 1 March 1989; 92 (3): 513–…

Common promoter variant in cyclooxygenase-2 represses gene expression: evidence of role in acute-phase inflammatory response

…, RP Marshall, SE Humphries, GJ Laurent - … , and vascular biology, 2002 - Am Heart Assoc
Objective— Cyclooxygenase (COX)-2 is a key regulatory enzyme in the synthesis of
prostanoids associated with trauma and inflammation. We investigated the COX-2 gene for …

Pulmonary fibrosis: searching for model answers

F Chua, J Gauldie, GJ Laurent - American journal of respiratory cell …, 2005 - atsjournals.org
Substantial challenges remain in our understanding of fibrotic lung diseases. Nowhere is this
more true than in the elucidation and verification of the pathogenetic basis upon which they …

Mast cell tryptase stimulates human lung fibroblast proliferation via protease-activated receptor-2

…, MD Hollenberg, S Sanjar, GJ Laurent… - … of Physiology-Lung …, 2000 - journals.physiology.org
Mast cells play a potentially important role in fibroproliferative diseases, releasing mediators
including tryptase that are capable of stimulating fibroblast proliferation and procollagen …

Fibroproliferation occurs early in the acute respiratory distress syndrome and impacts on outcome

…, N Goldsack, RJ McANULTY, GJ Laurent - American journal of …, 2000 - atsjournals.org
The fibroproliferative phase of acute respiratory distress syndrome (ARDS) has traditionally
been regarded as a late event but recent studies that suggest increased lung collagen …

Angiotensin II and the fibroproliferative response to acute lung injury

…, T Unger, RJ McAnulty, GJ Laurent - … of Physiology-Lung …, 2004 - journals.physiology.org
Angiotensin II (ANG II), generated by activation of local renin-angiotensin systems, is believed
to play an important role in tissue repair and remodeling, in part via transforming growth …

[HTML][HTML] Increased local expression of coagulation factor X contributes to the fibrotic response in human and murine lung injury

…, AG Nicholson, JD Moffatt, GJ Laurent… - The Journal of …, 2009 - Am Soc Clin Investig
Uncontrolled activation of the coagulation cascade contributes to the pathophysiology of
several conditions, including acute and chronic lung diseases. Coagulation zymogens are …

[HTML][HTML] Ligation of protease-activated receptor 1 enhances αv β6 integrin–dependent TGF-β activation and promotes acute lung injury

…, CJ Scotton, E Camerer, GJ Laurent… - The Journal of …, 2006 - Am Soc Clin Investig
Activation of latent TGF-β by the α v β 6 integrin is a critical step in the development of acute
lung injury. However, the mechanism by which α v β 6 -mediated TGF-β activation is …