Heterogeneity of quadriceps muscle phenotype in chronic obstructive pulmonary disease (COPD); implications for stratified medicine?

SA Natanek, HR Gosker, IGM Slot, GS Marsh… - Muscle & …, 2013 - Wiley Online Library
Gemma S. Marsh assisted SAN with collection of the muscle biopsies and physiological
testing and interpretation of the data. Nicholas S. Hopkinson helped with physiological testing, …

MuRF-1 and atrogin-1 protein expression and quadriceps fiber size and muscle mass in stable patients with COPD

…, J Riddoch-Contreras, GS Marsh… - COPD: Journal of …, 2013 - Taylor & Francis
Introduction: Animal studies demonstrate the importance of the E3 ubiquitin ligases, Muscle
RING-Finger Protein 1 (MuRF-1) and atrogin-1, in muscle protein degradation during acute …

Pathways associated with reduced quadriceps oxidative fibres and endurance in COPD

…, HR Gosker, IGM Slot, GS Marsh… - European …, 2013 - Eur Respiratory Soc
Reduced quadriceps endurance in chronic obstructive pulmonary disease (COPD) is
associated with a predominance of type II glycolytic fibres over type I oxidative fibres (fibre shift) …

p38 mitogen-activated protein kinase is not activated in the quadriceps of patients with stable chronic obstructive pulmonary disease

…, T George, SA Natanek, GS Marsh… - COPD: Journal of …, 2012 - Taylor & Francis
Quadriceps weakness is associated with a poor prognosis in COPD. Several data suggest
that immobility and muscle wasting may be related through up-regulation of the p38 Mitogen …

Alterations in MRTF and FHL1 activity contribute to fibre type shift in the quadriceps of patients with COPD

…, SA Natanek, GS Marsh… - … MUSCLE INJURY IN …, 2010 - atsjournals.org
Muscle loss and the associated weakness confer a poor prognosis in COPD, yet the molecular
pathways responsible are not Background well characterised. Serum response factor (…

Old but gold: tracking the new guise of histone deacetylase 6 (HDAC6) enzyme as a biomarker and therapeutic target in rare diseases

…, S Brogi, S Gemma, S Butini… - Journal of medicinal …, 2019 - ACS Publications
Epigenetic regulation orchestrates many cellular processes and greatly influences key
disease mechanisms. Histone deacetylase (HDAC) enzymes play a crucial role either as …

[BOOK][B] Structure-based design of drugs and other bioactive molecules: tools and strategies

AK Ghosh, S Gemma - 2014 - books.google.com
Drug design is a complex, challenging and innovative research area. Structure-based molecular
design has transformed the drug discovery approach in modern medicine. Traditionally, …

[HTML][HTML] Neuroprotective effects of toll-like receptor 4 antagonism in spinal cord cultures and in a mouse model of motor neuron degeneration

…, P Bigini, M Peviani, G Ferrara, M Molteni, S Gemma… - Molecular …, 2012 - Springer
Sustained inflammatory reactions are common pathological events associated with neuron
loss in neurodegenerative diseases. Reported evidence suggests that Toll-like receptor 4 (…

Structure-activity relationships, biological evaluation and structural studies of novel pyrrolonaphthoxazepines as antitumor agents

M Brindisi, C Ulivieri, G Alfano, S Gemma… - European journal of …, 2019 - Elsevier
Microtubule-targeting agents (MTAs) are a class of clinically successful anti-cancer drugs.
The emergence of multidrug resistance to MTAs imposes the need for developing new MTAs …

[HTML][HTML] Broad inhibition of plasmodium falciparum cytoadherence by (+)-epigallocatechin gallate

PR Patil, S Gemma, G Campiani, AG Craig - Malaria Journal, 2011 - Springer
Background The surface antigen Pf EMP-1 is a key virulence factor of the human malaria
parasite implicated in the cytoadherence of Plasmodium falciparum infected erythrocytes to a …