Heterogeneity of quadriceps muscle phenotype in chronic obstructive pulmonary disease (COPD); implications for stratified medicine?
SA Natanek, HR Gosker, IGM Slot, GS Marsh… - Muscle & …, 2013 - Wiley Online Library
… Gemma S. Marsh assisted SAN with collection of the muscle biopsies and physiological
testing and interpretation of the data. Nicholas S. Hopkinson helped with physiological testing, …
testing and interpretation of the data. Nicholas S. Hopkinson helped with physiological testing, …
MuRF-1 and atrogin-1 protein expression and quadriceps fiber size and muscle mass in stable patients with COPD
…, J Riddoch-Contreras, GS Marsh… - COPD: Journal of …, 2013 - Taylor & Francis
Introduction: Animal studies demonstrate the importance of the E3 ubiquitin ligases, Muscle
RING-Finger Protein 1 (MuRF-1) and atrogin-1, in muscle protein degradation during acute …
RING-Finger Protein 1 (MuRF-1) and atrogin-1, in muscle protein degradation during acute …
Pathways associated with reduced quadriceps oxidative fibres and endurance in COPD
…, HR Gosker, IGM Slot, GS Marsh… - European …, 2013 - Eur Respiratory Soc
Reduced quadriceps endurance in chronic obstructive pulmonary disease (COPD) is
associated with a predominance of type II glycolytic fibres over type I oxidative fibres (fibre shift) …
associated with a predominance of type II glycolytic fibres over type I oxidative fibres (fibre shift) …
p38 mitogen-activated protein kinase is not activated in the quadriceps of patients with stable chronic obstructive pulmonary disease
…, T George, SA Natanek, GS Marsh… - COPD: Journal of …, 2012 - Taylor & Francis
Quadriceps weakness is associated with a poor prognosis in COPD. Several data suggest
that immobility and muscle wasting may be related through up-regulation of the p38 Mitogen …
that immobility and muscle wasting may be related through up-regulation of the p38 Mitogen …
Alterations in MRTF and FHL1 activity contribute to fibre type shift in the quadriceps of patients with COPD
…, SA Natanek, GS Marsh… - … MUSCLE INJURY IN …, 2010 - atsjournals.org
Muscle loss and the associated weakness confer a poor prognosis in COPD, yet the molecular
pathways responsible are not Background well characterised. Serum response factor (…
pathways responsible are not Background well characterised. Serum response factor (…
Old but gold: tracking the new guise of histone deacetylase 6 (HDAC6) enzyme as a biomarker and therapeutic target in rare diseases
Epigenetic regulation orchestrates many cellular processes and greatly influences key
disease mechanisms. Histone deacetylase (HDAC) enzymes play a crucial role either as …
disease mechanisms. Histone deacetylase (HDAC) enzymes play a crucial role either as …
[BOOK][B] Structure-based design of drugs and other bioactive molecules: tools and strategies
Drug design is a complex, challenging and innovative research area. Structure-based molecular
design has transformed the drug discovery approach in modern medicine. Traditionally, …
design has transformed the drug discovery approach in modern medicine. Traditionally, …
[HTML][HTML] Neuroprotective effects of toll-like receptor 4 antagonism in spinal cord cultures and in a mouse model of motor neuron degeneration
…, P Bigini, M Peviani, G Ferrara, M Molteni, S Gemma… - Molecular …, 2012 - Springer
Sustained inflammatory reactions are common pathological events associated with neuron
loss in neurodegenerative diseases. Reported evidence suggests that Toll-like receptor 4 (…
loss in neurodegenerative diseases. Reported evidence suggests that Toll-like receptor 4 (…
Structure-activity relationships, biological evaluation and structural studies of novel pyrrolonaphthoxazepines as antitumor agents
M Brindisi, C Ulivieri, G Alfano, S Gemma… - European journal of …, 2019 - Elsevier
Microtubule-targeting agents (MTAs) are a class of clinically successful anti-cancer drugs.
The emergence of multidrug resistance to MTAs imposes the need for developing new MTAs …
The emergence of multidrug resistance to MTAs imposes the need for developing new MTAs …
[HTML][HTML] Broad inhibition of plasmodium falciparum cytoadherence by (+)-epigallocatechin gallate
Background The surface antigen Pf EMP-1 is a key virulence factor of the human malaria
parasite implicated in the cytoadherence of Plasmodium falciparum infected erythrocytes to a …
parasite implicated in the cytoadherence of Plasmodium falciparum infected erythrocytes to a …