Background During the first wave of the coronavirus disease 2019 (COVID-19) pandemic,
older patients had an increased risk of hospitalisation and death. Reports on the association …

Aims Several studies have reported the under‐representation of women in clinical trials,
thereby challenging the external validity of the benefit/risk assessments of launched drugs. Our …

The aim of this study is to compare the performance of two clinical decision rules to select
patients with acute pulmonary embolism (PE) for outpatient treatment: the Hestia criteria and …

Importance Although older patients are at increased risk of developing grade 3 or higher
chemotherapy-related toxic effects, no studies, to our knowledge, have focused on the …

We investigated whether the clinical criteria used in the Hestia study for selection of pulmonary
embolism (PE) patients for outpatient treatment could discriminate PE patients with high …

Background Treatment decisions concerning older patients can be very challenging and
individualised treatment plans are often required in this very heterogeneous group. In 2015 we …

Introduction Older adults with an acute moderate-to-severe lower respiratory tract infection (LRTI)
or pneumonia are generally treated in hospitals causing risk of iatrogenic harm such …

Introduction HTL0018318 is a selective muscarinic M 1 receptor partial agonist under development
for the symptomatic treatment of dementias, including Alzheimer’s disease. Clinically, …

Since the start of the COVID-19 pandemic, a hyperinflammatory syndrome has appeared
which develops weeks after a SARS-CoV-2 infection. This multisystem inflammatory syndrome …

In contrast to primary colorectal cancer (CRC) little is known about the genomic landscape of
metastasized CRC. Here we present whole genome sequencing data of metastases of 429 …