User profiles for Gary C. Sieck

Gary Sieck

Mayo Clinic
Verified email at Mayo.edu
Cited by 22696

Altered diaphragm contractile properties with controlled mechanical ventilation

…, VJ Caiozzo, A Manka, GC Sieck - Journal of applied …, 2002 - journals.physiology.org
This study shows that, over time, diaphragm inactivity with controlled mechanical ventilation
(CMV) decreases diaphragm force and produces myofibril damage contributing to the …

Oxidative capacity of human muscle fiber types: effects of age and training status

…, WE Sinning, JM Walro, GC Sieck… - Journal of applied …, 1995 - journals.physiology.org
Morphometry and oxidative capacity of slow-twitch (type I) and fast-twitch (type IIa and IIb)
muscle fibers obtained from vastus lateralis needle biopsies were compared between younger …

Diaphragm dysfunction in chronic obstructive pulmonary disease

CAC Ottenheijm, LMA Heunks, GC Sieck… - American journal of …, 2005 - atsjournals.org
Rationale: Hypercapnic respiratory failure because of inspiratory muscle weakness is the most
important cause of death in chronic obstructive pulmonary disease (COPD). However, the …

Effects of voluntary activity and genetic selection on aerobic capacity in house mice (Mus domesticus)

…, PA Carter, WZ Zhan, GC Sieck - Journal of applied …, 1998 - journals.physiology.org
… Carter, Wen-Zhi Zhan, and Gary C. Sieck. Effects of voluntary activity and genetic selection
… and wood shavings in a temperature-controlled room (∼22C) with a constant 12:12-h light-…

Diaphragm motor unit recruitment during ventilatory and nonventilatory behaviors

GC Sieck, M Fournier - Journal of Applied Physiology, 1989 - journals.physiology.org
The forces generated by the cat diaphragm (DIA) during different ventilatory and nonventilatory
behaviors were determined by measuring transdiaphragmatic pressures (Pdi). The Pdi …

Pressure-time product during continuous positive airway pressure, pressure support ventilation, and T-piece during weaning from mechanical ventilation

CS Sassoon, RW Light, R Lodia, GC Sieck… - Am Rev Respir …, 1991 - atsjournals.org
The objective of this study was to compare the effects of continuous positive airway pressure
(CPAP), pressure support ventilation (PS), and T. plece on the pressure-time product (PTP) …

[HTML][HTML] 1α, 25-Dihydroxyvitamin D3 regulates mitochondrial oxygen consumption and dynamics in human skeletal muscle cells

…, JL Salisbury, KS Nair, A Terzic, GC Sieck… - Journal of Biological …, 2016 - ASBMB
Muscle weakness and myopathy are observed in vitamin D deficiency and chronic renal
failure, where concentrations of the active vitamin D 3 metabolite, 1α,25-dihydroxyvitamin D 3 (…

Mitochondrial dysfunction in airway disease

YS Prakash, CM Pabelick, GC Sieck - Chest, 2017 - Elsevier
There is increasing appreciation that mitochondria serve cellular functions beyond oxygen
sensing and energy production. Accordingly, it has become important to explore …

Cigarette smoke-induced mitochondrial fragmentation and dysfunction in human airway smooth muscle

…, M Thompson, R Vassallo, GC Sieck… - … of Physiology-Lung …, 2014 - journals.physiology.org
The balance between mitochondrial fission and fusion is crucial for mitochondria to perform
its normal cellular functions. We hypothesized that cigarette smoke (CS) disrupts this …

Maximum specific force depends on myosin heavy chain content in rat diaphragm muscle fibers

…, MJ Cody, RL Macken, GC Sieck - Journal of applied …, 2000 - journals.physiology.org
In the present study, myosin heavy chain (MHC) content per half sarcomere, an estimate of
the number of cross bridges available for force generation, was determined in rat diaphragm …