Hyaluronic acid and its derivatives in drug delivery and imaging: Recent advances and challenges

G Tripodo, A Trapani, ML Torre, G Giammona… - European Journal of …, 2015 - Elsevier
Hyaluronic acid (HA) is a biodegradable, biocompatible, nontoxic, and non-immunogenic
glycosaminoglycan used for various biomedical applications. The interaction of HA with the …

Amoxicillin-loaded polyethylcyanoacrylate nanoparticles: influence of PEG coating on the particle size, drug release rate and phagocytic uptake

…, M Licciardi, S Mansueto, D Schillaci, G Giammona - Biomaterials, 2001 - Elsevier
Polyethyleneglycol (PEG)-coated polyethylcyanoacrylate (PECA) nanoparticles loaded with
amoxicillin were prepared and the influence of the PEG coating on the particle size, zeta …

Pefloxacine mesilate-and ofloxacin-loaded polyethylcyanoacrylate nanoparticles: characterization of the colloidal drug carrier formulation

M Fresta, G Puglisi, G Giammona, G Cavallaro… - Journal of …, 1995 - Elsevier
The entrapment of fluoroquinolones, perfloxacine mesilate (PFX) and ofloxacin (OFX), in
polyalkylcyanoacrylate (PECA) nanoparticles could offer some advantages for their biological …

Reaction of α,β‐poly(N‐hydroxyethyl)‐DL‐aspartamide with derivatives of carboxylic acids

G Giammona, B Carlisi… - Journal of Polymer Science …, 1987 - Wiley Online Library
Benzoic acid, acetylsalicylic acid, and 4‐acetamidobenzoic acid have been covalently
linked by ester bonds to α, β‐poly (N‐hydroxyethyl)‐dl‐aspartamide (PHEA), a water soluble …

Brain-targeted solid lipid nanoparticles containing riluzole: preparation, characterization and biodistribution

ML Bondì, EF Craparo, G Giammona, F Drago - Nanomedicine, 2010 - Future Medicine
Aim: Developments within nanomedicine have revealed a great potential for drug delivery to
the brain. In this study nanoparticulate systems as drug carriers for riluzole, with sufficiently …

Ferulic acid inhibits oxidative stress and cell death induced by Ab oligomers: Improved delivery by solid lipid nanoparticles

…, A Bruno, G Pitarresi, G Giammona… - Free Radical …, 2009 - Taylor & Francis
Oxidative stress and dysfunctional mitochondria are among the earliest events in AD, triggering
neurodegeneration. The use of natural antioxidants could be a neuroprotective strategy …

New graft copolymers of hyaluronic acid and polylactic acid: Synthesis and characterization

…, D Mandracchia, G Tripodo, G Giammona - Carbohydrate …, 2006 - Elsevier
New graft copolymers have been synthesized, using hyaluronic acid (HA) as a hydrophilic
backbone and polylactic acid (PLA) as an aliphatic polyester in order to obtain new polymeric …

Ocular tolerability and in vivo bioavailability of poly (ethylene glycol)(PEG)‐coated polyethyl‐2‐cyanoacrylate nanosphere‐encapsulated acyclovir

…, C Bucolo, G Cavallaro, G Giammona… - Journal of …, 2001 - Elsevier
Acyclovir‐loaded polyethyl‐2‐cyanoacrylate (PECA) nanospheres were prepared by an
emulsion polymerization process in the micellar phase and characterized. The influence of the …

Gellan gum-based delivery systems of therapeutic agents and cells

…, S Federico, G Pitarresi, C Fiorica, G Giammona - Carbohydrate …, 2020 - Elsevier
The purpose of this review is to make a summary of high quality research trends using gellan
gum (GG) as a polymeric constituent for the design of innovative drug delivery systems and …

New folate-functionalized biocompatible block copolymer micelles as potential anti-cancer drug delivery systems

M Licciardi, G Giammona, J Du, SP Armes, Y Tang… - Polymer, 2006 - Elsevier
The main objective of this study was to synthesize novel folic acid-functionalized diblock
copolymer micelles and evaluate their solubilization of two poorly water-soluble anti-tumor drugs…