Prions are the infectious agents responsible for transmissible spongiform encephalopathies.
The principal component of prions is the glycoprotein PrP Sc , which is a conformationally …

Background Transmissible spongiform encephalopathies are associated with a structural
transition in the prion protein that results in the conversion of the physiological PrP C to …

Genetic, neuropathological, and biochemical studies have provided strong evidence for a
central role of amyloid in the pathogenesis of Alzheimer's disease (AD). We have proposed …

Diverse human disorders, including the majority of neurodegenerative diseases, are thought
to arise from the misfolding and aggregation of protein. We have recently described a novel …

Transmissible spongiform encephalopathies display long incubation periods at the beginning
of which the titer of infectious agents (prions) increases in peripheral lymphoid organs. …

A conformational transition between the normal cellular prion protein (PrP C ) and the β-sheet-rich
pathological isoform (PrP Sc ) is a central event in the pathogenesis of spongiform …

Transmissible spongiform encephalopathies – also known as prion-related diseases – are
a group of fatal neurodegenerative disorders associated with the misfolding of prion protein. …

Background Recurrent acute exacerbations are generally associated with accelerated decline
of lung function and characterized by reduced physical activity and worsening of clinical …

Multiple sclerosis (MS) is a neuroinflammatory disease characterized by a progressive loss
of myelin and a failure of oligodendrocyte (OL)-mediated remyelination, particularly in the …

In prion diseases, the normal prion protein (PrP c ) undergoes a conformational change that
results in the abnormal form, named scrapie prion protein (PrP sc ). The visual system of …