Pulmonary actinomycosis

GF Mabeza, J Macfarlane - European Respiratory Journal, 2003 - Eur Respiratory Soc
Pulmonary actinomycosis is a rare but important and challenging diagnosis to make. Even
when the clinical suspicion is high, the disease is commonly confused with other chronic …

Iron chelation therapy for malaria: a review

GF Mabeza, M Loyevsky, VR Gordeuk… - Pharmacology & …, 1999 - Elsevier
… When DFO was combined with deferiprone, an additive interaction on plasmodial growth
suppression was observed (GF Mabeza, unpublished observations), implying that the two iron(…

Effect of iron chelation therapy on mortality in Zambian children with cerebral malaria

PE Thuma, GF Mabeza, G Biemba, GJ Bhat… - Transactions of the …, 1998 - Elsevier
To examine the effect of iron chelation on mortality in cerebral malaria, we enrolled 352 children
in a trial of deferoxamine in addition to standard quinine therapy at 2 centres in Zambia, …

Clinical studies of iron chelators in malaria

GF Mabeza, G Biemba, VR Gordeuk - Acta haematologica, 1996 - karger.com
In 75 Zambian and Thai subjects with mild to moderate infection with Plasmodium falciparum
or Plasmodium vivax, 3-day infusions of desferrioxamine B (100 mg/kg/day) as a single …

Prolonged macrophage activation and persistent anaemia in children with complicated malaria

…, VR Gordeuk, PE Thuma, GF Mabeza… - Tropical Medicine & …, 1998 - Wiley Online Library
objective To determine if prolonged immune activation may be associated with the persistence
of anaemia after treatment for severe malaria, we measured serum concentrations of …

Assessment of the effect of the oral iron chelator deferiprone on asymptomatic Plasmodium falciparum parasitemia in humans

P Thuma, NF Olivieri, GF Mabeza, G Biemba, D Parry… - 1998 - mosaic.messiah.edu
While the parenteral iron-chelating agent desferrioxamine B has anti-malarial activity in
humans, the usefulness of an orally active chelator for this indication has not been investigated …

A randomized controlled trial of artemotil (β-arteether) in Zambian children with cerebral malaria

P Thuma, GJ Bhat, GF Mabeza, C Osborne, G Biemba… - 2000 - mosaic.messiah.edu
The efficacy and safety of intramuscular artemotil (ARTECEF®) was compared to intravenous
quinine in African children with cerebral malaria. This prospective block randomized open-…

Predictors of severity of illness on presentation in children with cerebral malaria

GF Mabeza, VM Moyo, PE Thuma… - Annals of Tropical …, 1995 - Taylor & Francis
The presenting features of 195 children with cerebral malaria were analysed to determine
which correlated with severity of coma and anaemia. The children, who came from a single …

Loading dose of quinine in African children with cerebral malaria

M Van Der Torn, PE Thuma, GF Mabeza… - Transactions of the …, 1998 - academic.oup.com
The majority of deaths from cerebral malaria occur within 48 h after admission to hospital.
Because of the possibility of inadequate treatment within this period, the use of a loading dose …

The association of pallor with haemoglobin concentration and mortality in severe malaria

GF Mabeza, G Biemba, AG Brennan… - Annals of Tropical …, 1998 - Taylor & Francis
To identify a marker associated with poor outcome in severe malaria that requires no
technology, the relationship between the presence of pallor and mortality was reviewed …