User profiles for G. Walzl

Gerhard Walzl

Stellenbosch University
Verified email at sun.ac.za
Cited by 19812

Immunological biomarkers of tuberculosis

G Walzl, K Ronacher, W Hanekom, TJ Scriba… - Nature Reviews …, 2011 - nature.com
Currently there are no sufficiently validated biomarkers to aid the evaluation of new tuberculosis
vaccine candidates, the improvement of tuberculosis diagnostics or the development of …

Biomarkers and diagnostics for tuberculosis: progress, needs, and translation into practice

RS Wallis, M Pai, D Menzies, TM Doherty, G Walzl… - The lancet, 2010 - thelancet.com
Human infection with Mycobacterium tuberculosis can progress to active disease, be
contained as latent infection, or be eradicated by the host response. Tuberculosis diagnostics …

Tuberculosis: progress and advances in development of new drugs, treatment regimens, and host-directed therapies

S Tiberi, N du Plessis, G Walzl, MJ Vjecha… - The Lancet Infectious …, 2018 - thelancet.com
Tuberculosis remains the world's leading cause of death from an infectious disease,
responsible for an estimated 1 674 000 deaths annually. WHO estimated 600 000 cases of …

A blood RNA signature for tuberculosis disease risk: a prospective cohort study

…, S Shankar, SK Parida, SHE Kaufmann, G Walzl… - The Lancet, 2016 - thelancet.com
Background Identification of blood biomarkers that prospectively predict progression of
Mycobacterium tuberculosis infection to tuberculosis disease might lead to interventions that …

Distinct, specific IL-17-and IL-22-producing CD4+ T cell subsets contribute to the human anti-mycobacterial immune response

…, HY Hassan, RJ Wilkinson, G Walzl… - The Journal of …, 2008 - journals.aai.org
We investigated whether the proinflammatory T cell cytokines IL-17 and IL-22 are induced by
human mycobacterial infection. Remarkably,> 20% of specific cytokine-producing CD4+ T …

Diagnostic tools in tuberculous pleurisy: a direct comparative study

…, J Bezuidenhout, CT Bolliger, G Walzl - European …, 2003 - Eur Respiratory Soc
Thoracoscopy is the most accurate yet most expensive tool for establishing the diagnosis of
tuberculous (TB) pleurisy. However, most high TB‐incidence regions have limited financial …

Human gene expression profiles of susceptibility and resistance in tuberculosis

…, SK Parida, K Stanley, T Roberts, G Black, G Walzl… - Genes & …, 2011 - nature.com
Tuberculosis (TB) still poses a profound burden on global health, owing to significant morbidity
and mortality worldwide. Although a fully functional immune system is essential for the …

Genital inflammation and the risk of HIV acquisition in women

…, DA Lauffenburger, K Ronacher, G Walzl… - Clinical Infectious …, 2015 - academic.oup.com
Background. Women in Africa, especially young women, have very high human immunodeficiency
virus (HIV) incidence rates that cannot be fully explained by behavioral risks. We …

Persisting positron emission tomography lesion activity and Mycobacterium tuberculosis mRNA after tuberculosis cure

…, G Tromp, D Alland, CE Barry III, J Winter, G Walzl… - Nature medicine, 2016 - nature.com
The absence of a gold standard to determine when antibiotics induce a sterilizing cure has
confounded the development of new approaches to treat pulmonary tuberculosis (PTB). We …

Four-gene pan-African blood signature predicts progression to tuberculosis

…, SHE Kaufmann, DE Zak, G Walzl - American journal of …, 2018 - atsjournals.org
Rationale: Contacts of patients with tuberculosis (TB) constitute an important target population
for preventive measures because they are at high risk of infection with Mycobacterium …