User profiles for G. Walzl
Gerhard WalzlStellenbosch University Verified email at sun.ac.za Cited by 19812 |
Immunological biomarkers of tuberculosis
Currently there are no sufficiently validated biomarkers to aid the evaluation of new tuberculosis
vaccine candidates, the improvement of tuberculosis diagnostics or the development of …
vaccine candidates, the improvement of tuberculosis diagnostics or the development of …
Biomarkers and diagnostics for tuberculosis: progress, needs, and translation into practice
Human infection with Mycobacterium tuberculosis can progress to active disease, be
contained as latent infection, or be eradicated by the host response. Tuberculosis diagnostics …
contained as latent infection, or be eradicated by the host response. Tuberculosis diagnostics …
Tuberculosis: progress and advances in development of new drugs, treatment regimens, and host-directed therapies
Tuberculosis remains the world's leading cause of death from an infectious disease,
responsible for an estimated 1 674 000 deaths annually. WHO estimated 600 000 cases of …
responsible for an estimated 1 674 000 deaths annually. WHO estimated 600 000 cases of …
A blood RNA signature for tuberculosis disease risk: a prospective cohort study
…, S Shankar, SK Parida, SHE Kaufmann, G Walzl… - The Lancet, 2016 - thelancet.com
Background Identification of blood biomarkers that prospectively predict progression of
Mycobacterium tuberculosis infection to tuberculosis disease might lead to interventions that …
Mycobacterium tuberculosis infection to tuberculosis disease might lead to interventions that …
Distinct, specific IL-17-and IL-22-producing CD4+ T cell subsets contribute to the human anti-mycobacterial immune response
We investigated whether the proinflammatory T cell cytokines IL-17 and IL-22 are induced by
human mycobacterial infection. Remarkably,> 20% of specific cytokine-producing CD4+ T …
human mycobacterial infection. Remarkably,> 20% of specific cytokine-producing CD4+ T …
Diagnostic tools in tuberculous pleurisy: a direct comparative study
…, J Bezuidenhout, CT Bolliger, G Walzl - European …, 2003 - Eur Respiratory Soc
Thoracoscopy is the most accurate yet most expensive tool for establishing the diagnosis of
tuberculous (TB) pleurisy. However, most high TB‐incidence regions have limited financial …
tuberculous (TB) pleurisy. However, most high TB‐incidence regions have limited financial …
Human gene expression profiles of susceptibility and resistance in tuberculosis
Tuberculosis (TB) still poses a profound burden on global health, owing to significant morbidity
and mortality worldwide. Although a fully functional immune system is essential for the …
and mortality worldwide. Although a fully functional immune system is essential for the …
Genital inflammation and the risk of HIV acquisition in women
Background. Women in Africa, especially young women, have very high human immunodeficiency
virus (HIV) incidence rates that cannot be fully explained by behavioral risks. We …
virus (HIV) incidence rates that cannot be fully explained by behavioral risks. We …
Persisting positron emission tomography lesion activity and Mycobacterium tuberculosis mRNA after tuberculosis cure
The absence of a gold standard to determine when antibiotics induce a sterilizing cure has
confounded the development of new approaches to treat pulmonary tuberculosis (PTB). We …
confounded the development of new approaches to treat pulmonary tuberculosis (PTB). We …
Four-gene pan-African blood signature predicts progression to tuberculosis
…, SHE Kaufmann, DE Zak, G Walzl - American journal of …, 2018 - atsjournals.org
Rationale: Contacts of patients with tuberculosis (TB) constitute an important target population
for preventive measures because they are at high risk of infection with Mycobacterium …
for preventive measures because they are at high risk of infection with Mycobacterium …