User profiles for G. K. Singhera
 | Gurpreet SingheraCentre for Heart Lung Innovation Verified email at hli.ubc.ca Cited by 2382 |
ACE-2 expression in the small airway epithelia of smokers and COPD patients: implications for COVID-19
…, T Shaipanich, TL Hackett, GK Singhera… - European …, 2020 - Eur Respiratory Soc
The World Health Organization (WHO) has declared coronavirus disease 2019 (COVID-19)
a pandemic [1]. COVID-19 is caused by severe acute respiratory syndrome coronavirus 2 (…
a pandemic [1]. COVID-19 is caused by severe acute respiratory syndrome coronavirus 2 (…
Intrinsic phenotypic differences of asthmatic epithelium and its inflammatory responses to respiratory syncytial virus and air pollution
TL Hackett, GK Singhera, F Shaheen… - American journal of …, 2011 - atsjournals.org
A substantial proportion of healthcare cost associated with asthma is attributable to exacerbations
of the disease. Within the airway, the epithelium forms the mucosal immune barrier, …
of the disease. Within the airway, the epithelium forms the mucosal immune barrier, …
Toll-like receptor 4-mediated activation of p38 mitogen-activated protein kinase is a determinant of respiratory virus entry and tropism
D Marchant, GK Singhera, S Utokaparch… - Journal of …, 2010 - Am Soc Microbiol
Respiratory viruses exert a heavy toll of morbidity and mortality worldwide. Despite this
burden there are few specific treatments available for respiratory virus infections. Since many …
burden there are few specific treatments available for respiratory virus infections. Since many …
Secretion of IL-13 by airway epithelial cells enhances epithelial repair via HB-EGF
Inappropriate repair after injury to the epithelium generates persistent activation, which may
contribute to airway remodeling. In the present study we hypothesized that IL-13 is a normal …
contribute to airway remodeling. In the present study we hypothesized that IL-13 is a normal …
[HTML][HTML] Lipid nanoparticle formulations for optimal RNA-based topical delivery to murine airways
…, K An, L Li, DR Dorscheid, GK Singhera… - European Journal of …, 2022 - Elsevier
Introduction: Lipid nanoparticles (LNP) have been successfully used as a platform technology
for delivering nucleic acids to the liver. To broaden the application of LNPs in targeting non…
for delivering nucleic acids to the liver. To broaden the application of LNPs in targeting non…
[HTML][HTML] Airway Epithelial-Derived Immune Mediators in COVID-19
TJF Guo, GK Singhera, JM Leung, DR Dorscheid - Viruses, 2023 - mdpi.com
The airway epithelium, which lines the conducting airways, is central to the defense of the
lungs against inhaled particulate matter and pathogens such as SARS-CoV-2, the virus that …
lungs against inhaled particulate matter and pathogens such as SARS-CoV-2, the virus that …
Dysregulation of endocytic machinery and ACE2 in small airways of smokers and COPD patients can augment their susceptibility to SARS-CoV-2 (COVID-19) …
Lungs of smokers and chronic obstructive pulmonary disease (COPD) are severely
compromised and are susceptible to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2…
compromised and are susceptible to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2…
Increased myofibroblasts in the small airways, and relationship to remodelling and functional changes in smokers and COPD patients: potential role of epithelial …
Introduction Previous reports have shown epithelial–mesenchymal transition (EMT) as an
active process that contributes to small airway fibrotic pathology. Myofibroblasts are highly …
active process that contributes to small airway fibrotic pathology. Myofibroblasts are highly …
Erythropoietin inhibits respiratory epithelial cell apoptosis in a model of acute lung injury
R MacRedmond, GK Singhera… - European Respiratory …, 2009 - Eur Respiratory Soc
Fas-mediated apoptosis of the alveolar epithelium is important in the pathogenesis of acute
respiratory distress syndrome. Erythropoietin (EPO) has cytoprotective properties in other …
respiratory distress syndrome. Erythropoietin (EPO) has cytoprotective properties in other …
[HTML][HTML] Transforming growth factor-β1 and SMAD signalling pathway in the small airways of smokers and patients with COPD: potential role in driving fibrotic type-2 …
…, G Haug, J Larby, A Hardikar, GK Singhera… - Frontiers in …, 2023 - frontiersin.org
Background COPD is a common disease characterized by respiratory airflow obstruction.
TGF-β1 and SMAD pathway is believed to play a role in COPD pathogenesis by driving …
TGF-β1 and SMAD pathway is believed to play a role in COPD pathogenesis by driving …