Twice daily N-acetylcysteine 600 mg for exacerbations of chronic obstructive pulmonary disease (PANTHEON): a randomised, double-blind placebo-controlled trial

JP Zheng, FQ Wen, CX Bai, HY Wan, J Kang… - The Lancet …, 2014 - thelancet.com
Background Increased oxidative stress and inflammation has a role in the pathogenesis of
chronic obstructive pulmonary disease (COPD). Drugs with antioxidant and anti-inflammatory …

Matrix metalloproteinase-9 activates TGF-β and stimulates fibroblast contraction of collagen gels

…, T Kohyama, Q Fang, FQ Wen… - … of Physiology-Lung …, 2014 - journals.physiology.org
Matrix metalloproteinase-9 (MMP-9) is a matrix-degrading enzyme implicated in many
biological processes, including inflammation. It is produced by many cells, including fibroblasts. …

[HTML][HTML] The multifaceted therapeutic role of N-acetylcysteine (NAC) in disorders characterized by oxidative stress

…, G Marenzi, L Richeldi, FQ Wen… - Current …, 2021 - ncbi.nlm.nih.gov
Oxidative stress, which results in the damage of diverse biological molecules, is a
ubiquitous cellular process implicated in the etiology of many illnesses. The sulfhydryl-containing …

TH2 Cytokine-enhanced and TGF-β-enhanced vascular endothelial growth factor production by cultured human airway smooth muscle cells is attenuated by IFN-γ …

FQ Wen, X Liu, W Manda, Y Terasaki… - Journal of allergy and …, 2003 - Elsevier
Background: T H 2 and T H 1 cytokines have opposite effects on many aspects of the
inflammatory response. Methods: This study was designed to determine if cytokines possibly …

Cells derived from the circulation contribute to the repair of lung injury

S Abe, C Boyer, X Liu, FQ Wen… - American journal of …, 2004 - atsjournals.org
Bone marrow (stem/progenitor) cells have been shown to “differentiate” into cells in multiple
tissues, including lung. A low number of hematopoietic stem/progenitor cells also circulate in …

[HTML][HTML] Emodin ameliorates LPS-induced acute lung injury, involving the inactivation of NF-κB in mice

…, W Zhang, T Wang, YC Shen, QF Wan, FQ Wen - International journal of …, 2014 - mdpi.com
Fu-Qiang Wen and Min Xiao conceived the study design, collected, analyzed the data, and
wrote the manuscript. Min Xiao, Tao Zhu, Wei Zhang and Qiong-Fang Wan performed the …

Interleukin-4–and interleukin-13–enhanced transforming growth factor-β 2 production in cultured human bronchial epithelial cells is attenuated by interferon-γ

FQ Wen, T Kohyama, X Liu, YK Zhu… - American journal of …, 2002 - atsjournals.org
Cytokines derived from lymphocytes are believed to play key roles in a variety of diseases,
including airway diseases such as asthma. The current study was designed to evaluate the …

[HTML][HTML] Diagnostic performance of lung ultrasound in the diagnosis of pneumonia: a bivariate meta-analysis

…, HY Long, CS Pang, T Yang, FQ Wen - … journal of clinical and …, 2014 - ncbi.nlm.nih.gov
Background and Objective: Pneumonia is a common disease with both high morbidity and
mortality, the diagnosis of pneumonia remains a clinical challenge. Many studies have been …

Expert consensus on acute exacerbation of chronic obstructive pulmonary disease in the People's Republic of China

…, Y Song, T Sun, C Wang, J Wang, F Wen… - … journal of chronic …, 2014 - Taylor & Francis
Chronic obstructive pulmonary disease (COPD) is a common disease that severely threatens
human health. Acute exacerbation of COPD (AECOPD) is a major cause of disease …

[PDF][PDF] Diagnostic accuracy of adenosine deaminase for tuberculous peritonitis: a meta-analysis

…, L Chen, T Yang, C Wan, Q Hu, F Wen - Archives of Medical …, 2013 - termedia.pl
Results: Sixteen studies met inclusion criteria for the present meta-analysis. The pooled
sensitivity and specificity for diagnosing tuberculous peritonitis were 0.93 (95% CI: 0.89–0.95) …