[HTML][HTML] Progress and future of in vitro models to study translocation of nanoparticles

HM Braakhuis, SK Kloet, S Kezic, F Kuper… - Archives of …, 2015 - Springer
The increasing use of nanoparticles in products likely results in increased exposure of both
workers and consumers. Because of their small size, there are concerns that nanoparticles …

[HTML][HTML] Nonproliferative and proliferative lesions of the Ratand mouse special sense organs (ocular [eye and glands], olfactory and Otic)

…, M Jacobsen, U Junker-Walker, F Kuper… - Journal of Toxicologic …, 2018 - ncbi.nlm.nih.gov
… Meg Ferrell Ramos, Co-Chair, 1, a, * Julia Baker, Co-Chair, 2, a Elke-Astrid Atzpodien, 3,
a Ute Bach, 4, a Jacqueline Brassard, 5, a James Cartwright, 6, a Cynthia Farman, 7, a …

Transmaternal bisphenol A exposure accelerates diabetes type 1 development in NOD mice

J Bodin, AK Bølling, R Becher, F Kuper… - Toxicological …, 2014 - academic.oup.com
Diabetes mellitus type 1 is an autoimmune disease with a genetic predisposition that is
triggered by environmental factors during early life. Epidemiological studies show that bisphenol …

The role of nasopharyngeal lymphoid tissue

CF Kuper, PJ Koornstra, DMH Hameleers, J Biewenga… - Immunology today, 1992 - cell.com
Nasal-associated lymphoid tissue (NAL T), which comprises paired lymphoid organs in the
nasopharynx of rodents, is the principal mucosal lymphoid tissue of the respiratory tract. As …

[HTML][HTML] Exposure to bisphenol A, but not phthalates, increases spontaneous diabetes type 1 development in NOD mice

…, AK Bølling, A Wendt, L Eliasson, R Becher, F Kuper… - Toxicology reports, 2015 - Elsevier
Type 1 diabetes mellitus (T1DM) is an autoimmune destruction of insulin producing pancreatic
beta-cells due to a genetic predisposition and can be triggered by environmental factors. …

Molecular signature of asthma-enhanced sensitivity to CuO nanoparticle aerosols from 3D cell model

…, E Duistermaat, PC Tromp, F Kuper… - Acs Nano, 2019 - ACS Publications
More than 5% of any population suffers from asthma, and there are indications that these
individuals are more sensitive to nanoparticle aerosols than the healthy population. We used …

Chemical Respiratory Allergy: Opportunities for Hazard Identification and Characterisation: The Report and Recommendations of ECVAM Workshop 60

…, L Greenwell, T Hartung, F Kuper… - Alternatives to …, 2007 - journals.sagepub.com
This is the 60th Report of a series of workshops organised by the European Centre for the
Validation of Alternative Methods (ECVAM). The main goal of ECVAM, as defined in 1993 by …

Viability, function and morphological integrity of precision-cut liver slices during prolonged incubation: Effects of culture medium

…, GB Abza, HC Maessen, MT Merema, F Kuper… - Toxicology in Vitro, 2015 - Elsevier
Precision-cut liver slices (PCLS) are an ex vivo model for metabolism and toxicity studies.
However, data on the maintenance of the morphological integrity of the various cell types in …

Factors of concern in a human 3D cellular airway model exposed to aerosols of nanoparticles

IM Kooter, M Gröllers-Mulderij, E Duistermaat, F Kuper… - Toxicology in Vitro, 2017 - Elsevier
Mucilair 3D bronchial airway models, cultured at an air-liquid interface, were exposed to
aerosols of copper oxide (CuO) nanoparticles in Vitrocell air exposure modules. Four cell donors…

Five-day inhalation toxicity study of three types of synthetic amorphous silicas in Wistar rats and post-exposure evaluations for up to 3 months

…, H Muijser, E Duistermaat, K Junker, CF Kuper - Food and chemical …, 2007 - Elsevier
Evidence suggests that short-term animal exposures to synthetic amorphous silicas (SAS)
and crystalline silica can provide comparable prediction of toxicity to those of 90-day studies, …