[HTML][HTML] Progress and future of in vitro models to study translocation of nanoparticles
HM Braakhuis, SK Kloet, S Kezic, F Kuper… - Archives of …, 2015 - Springer
The increasing use of nanoparticles in products likely results in increased exposure of both
workers and consumers. Because of their small size, there are concerns that nanoparticles …
workers and consumers. Because of their small size, there are concerns that nanoparticles …
[HTML][HTML] Nonproliferative and proliferative lesions of the Ratand mouse special sense organs (ocular [eye and glands], olfactory and Otic)
…, M Jacobsen, U Junker-Walker, F Kuper… - Journal of Toxicologic …, 2018 - ncbi.nlm.nih.gov
… Meg Ferrell Ramos, Co-Chair, 1, a, * Julia Baker, Co-Chair, 2, a Elke-Astrid Atzpodien, 3,
a Ute Bach, 4, a Jacqueline Brassard, 5, a James Cartwright, 6, a Cynthia Farman, 7, a …
a Ute Bach, 4, a Jacqueline Brassard, 5, a James Cartwright, 6, a Cynthia Farman, 7, a …
Transmaternal bisphenol A exposure accelerates diabetes type 1 development in NOD mice
Diabetes mellitus type 1 is an autoimmune disease with a genetic predisposition that is
triggered by environmental factors during early life. Epidemiological studies show that bisphenol …
triggered by environmental factors during early life. Epidemiological studies show that bisphenol …
The role of nasopharyngeal lymphoid tissue
CF Kuper, PJ Koornstra, DMH Hameleers, J Biewenga… - Immunology today, 1992 - cell.com
Nasal-associated lymphoid tissue (NAL T), which comprises paired lymphoid organs in the
nasopharynx of rodents, is the principal mucosal lymphoid tissue of the respiratory tract. As …
nasopharynx of rodents, is the principal mucosal lymphoid tissue of the respiratory tract. As …
[HTML][HTML] Exposure to bisphenol A, but not phthalates, increases spontaneous diabetes type 1 development in NOD mice
Type 1 diabetes mellitus (T1DM) is an autoimmune destruction of insulin producing pancreatic
beta-cells due to a genetic predisposition and can be triggered by environmental factors. …
beta-cells due to a genetic predisposition and can be triggered by environmental factors. …
Molecular signature of asthma-enhanced sensitivity to CuO nanoparticle aerosols from 3D cell model
…, E Duistermaat, PC Tromp, F Kuper… - Acs Nano, 2019 - ACS Publications
More than 5% of any population suffers from asthma, and there are indications that these
individuals are more sensitive to nanoparticle aerosols than the healthy population. We used …
individuals are more sensitive to nanoparticle aerosols than the healthy population. We used …
Chemical Respiratory Allergy: Opportunities for Hazard Identification and Characterisation: The Report and Recommendations of ECVAM Workshop 60
…, L Greenwell, T Hartung, F Kuper… - Alternatives to …, 2007 - journals.sagepub.com
This is the 60th Report of a series of workshops organised by the European Centre for the
Validation of Alternative Methods (ECVAM). The main goal of ECVAM, as defined in 1993 by …
Validation of Alternative Methods (ECVAM). The main goal of ECVAM, as defined in 1993 by …
Viability, function and morphological integrity of precision-cut liver slices during prolonged incubation: Effects of culture medium
…, GB Abza, HC Maessen, MT Merema, F Kuper… - Toxicology in Vitro, 2015 - Elsevier
Precision-cut liver slices (PCLS) are an ex vivo model for metabolism and toxicity studies.
However, data on the maintenance of the morphological integrity of the various cell types in …
However, data on the maintenance of the morphological integrity of the various cell types in …
Factors of concern in a human 3D cellular airway model exposed to aerosols of nanoparticles
IM Kooter, M Gröllers-Mulderij, E Duistermaat, F Kuper… - Toxicology in Vitro, 2017 - Elsevier
Mucilair 3D bronchial airway models, cultured at an air-liquid interface, were exposed to
aerosols of copper oxide (CuO) nanoparticles in Vitrocell air exposure modules. Four cell donors…
aerosols of copper oxide (CuO) nanoparticles in Vitrocell air exposure modules. Four cell donors…
Five-day inhalation toxicity study of three types of synthetic amorphous silicas in Wistar rats and post-exposure evaluations for up to 3 months
…, H Muijser, E Duistermaat, K Junker, CF Kuper - Food and chemical …, 2007 - Elsevier
Evidence suggests that short-term animal exposures to synthetic amorphous silicas (SAS)
and crystalline silica can provide comparable prediction of toxicity to those of 90-day studies, …
and crystalline silica can provide comparable prediction of toxicity to those of 90-day studies, …