Farm dust and endotoxin protect against allergy through A20 induction in lung epithelial cells
…, MJ Ege, FB Madeira, R Beyaert, G van Loo, F Bracher… - Science, 2015 - science.org
Growing up on a dairy farm protects children from allergy, hay fever, and asthma. A mechanism
linking exposure to this endotoxin (bacterial lipopolysaccharide)–rich environment with …
linking exposure to this endotoxin (bacterial lipopolysaccharide)–rich environment with …
[HTML][HTML] PIM serine/threonine kinases in the pathogenesis and therapy of hematologic malignancies and solid cancers
The identification as cooperating targets of Proviral Integrations of Moloney virus in murine
lymphomas suggested early on that PIM serine/threonine kinases play an important role in …
lymphomas suggested early on that PIM serine/threonine kinases play an important role in …
[PDF][PDF] Specific CLK inhibitors from a novel chemotype for regulation of alternative splicing
…, LJ Jensen, D Fabbro, J Trappe, U Rauch, F Bracher… - Chemistry & biology, 2011 - cell.com
There is a growing recognition of the importance of protein kinases in the control of alternative
splicing. To define the underlying regulatory mechanisms, highly selective inhibitors are …
splicing. To define the underlying regulatory mechanisms, highly selective inhibitors are …
Single and combined toxicity of pharmaceuticals at environmentally relevant concentrations in Daphnia magna–A multigenerational study
S Dietrich, F Ploessl, F Bracher, C Laforsch - Chemosphere, 2010 - Elsevier
Pharmaceuticals are continuously discharged into the environment, resulting in the chronic
exposure of aquatic organisms to these compounds. In this multigenerational study, we …
exposure of aquatic organisms to these compounds. In this multigenerational study, we …
[HTML][HTML] High susceptibility to fatty liver disease in two-pore channel 2-deficient mice
…, O Griesbeck, A Haas, M Mann, F Bracher… - Nature …, 2014 - nature.com
Endolysosomal organelles play a key role in trafficking, breakdown and receptor-mediated
recycling of different macromolecules such as low-density lipoprotein (LDL)-cholesterol, …
recycling of different macromolecules such as low-density lipoprotein (LDL)-cholesterol, …
Agonist-mediated switching of ion selectivity in TPC2 differentially promotes lysosomal function
…, M Schaefer, M Biel, R Malli, C Wahl-Schott, F Bracher… - Elife, 2020 - elifesciences.org
Ion selectivity is a defining feature of a given ion channel and is considered immutable. Here
we show that ion selectivity of the lysosomal ion channel TPC2, which is hotly debated (…
we show that ion selectivity of the lysosomal ion channel TPC2, which is hotly debated (…
Multiresidue analytical method using dispersive solid-phase extraction and gas chromatography/ion trap mass spectrometry to determine pharmaceuticals in whole …
F Plössl, M Giera, F Bracher - Journal of Chromatography A, 2006 - Elsevier
A convenient analytical method for the simultaneous determination of more than 40
pharmaceuticals belonging to various therapeutic categories in whole blood has been developed. …
pharmaceuticals belonging to various therapeutic categories in whole blood has been developed. …
Accumulation of 8, 9-unsaturated sterols drives oligodendrocyte formation and remyelination
Regeneration of myelin is mediated by oligodendrocyte progenitor cells—an abundant stem
cell population in the central nervous system (CNS) and the principal source of new …
cell population in the central nervous system (CNS) and the principal source of new …
[HTML][HTML] A small molecule restores function to TRPML1 mutant isoforms responsible for mucolipidosis type IV
…, N Urban, A Wolfgardt, M Schaefer, F Bracher… - Nature …, 2014 - nature.com
Mucolipidosis type IV (MLIV) is an autosomal recessive lysosomal storage disorder often
characterized by severe neurodevelopmental abnormalities and neuro-retinal degeneration. …
characterized by severe neurodevelopmental abnormalities and neuro-retinal degeneration. …
[HTML][HTML] Benzodiazepines and benzotriazepines as protein interaction inhibitors targeting bromodomains of the BET family
…, M Keller, M Wrobel, O Morgenstern, F Bracher… - Bioorganic & medicinal …, 2012 - Elsevier
Benzodiazepines are psychoactive drugs with anxiolytic, sedative, skeletal muscle relaxant
and amnestic properties. Recently triazolo-benzodiazepines have been also described as …
and amnestic properties. Recently triazolo-benzodiazepines have been also described as …