Metal-rich Ambient Particles (Particulate Matter2.5) Cause Airway Inflammation in Healthy Subjects
F Schaumann, PJA Borm, A Herbrich… - American journal of …, 2004 - atsjournals.org
Epidemiologic studies have shown an increased prevalence of allergic asthma in children
living in a German smelter area (Hettstedt) compared with a cohort who live in a …
living in a German smelter area (Hettstedt) compared with a cohort who live in a …
Roflumilast attenuates pulmonary inflammation upon segmental endotoxin challenge in healthy subjects: a randomized placebo-controlled trial
…, M Lavae-Mokhtari, F Schaumann… - Pulmonary …, 2008 - Elsevier
RATIONALE: Roflumilast, an investigational, targeted phosphodiesterase 4 inhibitor,
reduces the in vitro and in vivo inflammatory activity of cells such as neutrophils, eosinophils, …
reduces the in vitro and in vivo inflammatory activity of cells such as neutrophils, eosinophils, …
Endotoxin augments myeloid dendritic cell influx into the airways in patients with allergic asthma
F Schaumann, M Müller, A Braun… - American journal of …, 2008 - atsjournals.org
Rationale: Epidemiologic studies have shown that exacerbation of asthma is modulated by
environmental endotoxin. High levels of endotoxin are associated with asthma symptoms …
environmental endotoxin. High levels of endotoxin are associated with asthma symptoms …
[HTML][HTML] Low-dose endotoxin inhalation in healthy volunteers-a challenge model for early clinical drug development
O Janssen, F Schaumann, O Holz… - BMC Pulmonary …, 2013 - Springer
Background Inhalation of endotoxin (LPS) induces a predominantly neutrophilic airway
inflammation and has been used as model to test the anti-inflammatory activity of novel drugs. In …
inflammation and has been used as model to test the anti-inflammatory activity of novel drugs. In …
Allergen challenge increases anandamide in bronchoalveolar fluid of patients with allergic asthma
Preclinical studies suggest that the endocannabinoid anandamide restrains allergic airway
obstruction and inflammation. Therefore, we applied saline or allergens via bronchoscopy …
obstruction and inflammation. Therefore, we applied saline or allergens via bronchoscopy …
[HTML][HTML] Effect of diet on serum creatinine in healthy subjects during a phase I study
…, M Jensen, D Jung, F Schaumann… - Journal of clinical …, 2016 - ncbi.nlm.nih.gov
Creatinine is widely used as an indirect marker of renal function. However, interfering
factors such as diet, exercise and problems with the assay can generate false results and …
factors such as diet, exercise and problems with the assay can generate false results and …
[HTML][HTML] Effects of ultrafine particles on the allergic inflammation in the lung of asthmatics: results of a double-blinded randomized cross-over clinical pilot study
F Schaumann, C Frömke, D Dijkstra… - Particle and fibre …, 2014 - Springer
Background Epidemiological and experimental studies suggest that exposure to ultrafine
particles (UFP) might aggravate the allergic inflammation of the lung in asthmatics. Methods …
particles (UFP) might aggravate the allergic inflammation of the lung in asthmatics. Methods …
Quantification of pulmonary inflammation after segmental allergen challenge using turbo-inversion recovery-magnitude magnetic resonance imaging
…, C Schönfeld, M Gutberlet, F Schaumann… - American journal of …, 2014 - atsjournals.org
Rationale: There is a need to develop novel noninvasive imaging biomarkers that help to
evaluate antiinflammatory asthma treatments. Objectives: To investigate whether the extent of …
evaluate antiinflammatory asthma treatments. Objectives: To investigate whether the extent of …
Segmental allergen challenge alters multimeric structure and function of surfactant protein D in humans
…, C Winkler, H Abramova, F Schaumann… - American journal of …, 2011 - atsjournals.org
Rationale: Surfactant protein D (SP-D), a 43-kD collectin, is synthesized and secreted by
airway epithelia as a dodecamer formed by assembly of four trimeric subunits. We have …
airway epithelia as a dodecamer formed by assembly of four trimeric subunits. We have …
Noninvasive quantification of airway inflammation following segmental allergen challenge with functional MR imaging: a proof of concept study
…, C Winkler, C Faulenbach, P Jakob, F Schaumann… - Radiology, 2015 - pubs.rsna.org
Purpose To evaluate oxygen-enhanced T1-mapping magnetic resonance (MR) imaging as
a noninvasive method for visualization and quantification of regional inflammation after …
a noninvasive method for visualization and quantification of regional inflammation after …