We investigated the role of hepatocyte apoptosis in four different murine models of acute
inflammatory liver failure. Liver damage induced in D-galactosamine-sensitized mice by …

Concanavalin A activates T lymphocytes in vitro and causes T-cell-dependent hepatic injury
in mice. T lymphocytes were previously identified as effector cells of concanavalin A—…

Freshly isolated mouse hepatocytes were essentially insensitive to TNF-alpha cytotoxicity.
However, TNF-alpha induced a concentration-dependent cell death in hepatocytes that had …

Background & Aims: T cell–dependent liver injury in- receptor deficiency5 prevented mice
from LPS lethality. volving endogenous tumor necrosis factor (TNF) a can These effects were …

The systemic inflammatory response is characterized by release of circulating TNF which
may cause multiorgan failure including septic liver failure. We studied TNF signaling in an …

We explored the ex vivo alteration in the cytokine release of stimulated blood taken from
healthy volunteers treated subcutaneously with 480 micrograms granulocyte colony-stimulating …

In a double-blind, placebo-controlled, randomized study, 10 healthy men received either a
single dose of 480 μg granulocyte colony-stimulating factor (G-CSF) or saline. Blood taken …

Histamine is known to trigger the release of interleukin (IL)-16 from human CD8 + cells.
However, the individual roles of the presently known histamine receptor subtypes (H 1 -H 4 ) in …

BACKGROUND & AIMS: Treatment with tumor necrosis factor (TNF) induces murine hepatocyte
apoptosis in vitro and in vivo when sensitizing concentrations of toxins are present. The …

Ramatroban (Baynas, BAY u3405), a thromboxane A 2 (TxA 2 ) antagonist marketed for allergic
rhinitis, has been shown to partially attenuate prostaglandin (PG)D 2 -induced bronchial …