Bronchiectasis in adults is a chronic disorder associated with poor quality of life and frequent
exacerbations in many patients. There have been no previous international guidelines. The …

Background Cystic fibrosis is an autosomal recessive disease caused by mutations in the
CFTR gene that lead to progressive respiratory decline. Some mutant CFTR proteins show …

There is a need for a clear definition of exacerbations used in clinical trials in patients with
bronchiectasis. An expert conference was convened to develop a consensus definition of an …

Rationale: Improved therapeutic options are needed for patients with treatment-refractory
nontuberculous mycobacterial lung disease caused by Mycobacterium avium complex (MAC). …

Bronchiectasis refers to both a clinical disease and a radiological appearance that has multiple
causes and can be associated with a range of conditions. Disease heterogeneity and the …

Background Representative population-based data on the epidemiology of bronchiectasis
in Europe are limited. The aim of the present study was to investigate the current burden and …

Bronchiectasis is a disease of renewed interest in light of an increase in prevalence and
increasing burden on international healthcare systems. There are no licensed therapies, and …

Methods Participants who completed the last visit of the 24-week treatment period in the F/MF
pivotal study (NCT03525444) or of the 4-week treatment period in the F/F pivotal study (…

Rationale: The CFTR (cystic fibrosis transmembrane conductance regulator) modulator
combination elexacaftor/tezacaftor/ivacaftor (ELX/TEZ/IVA) was shown to improve clinical …

Bronchiectasis is one of the most neglected diseases in respiratory medicine. There are no
approved therapies and few large-scale, representative epidemiological studies. The …