User profiles for Fang Gao Smith

Fang Gao Smith

Professor of Anaesthesia, Critical Care and Pain, Birmingham University
Verified email at bham.ac.uk
Cited by 14950

Paravertebral block versus thoracic epidural for patients undergoing thoracotomy

…, BV Naidu, MJA Wilson, FG Smith - Cochrane Database …, 2016 - cochranelibrary.com
Background Operations on structures in the chest (usually the lungs) involve cutting between
the ribs (thoracotomy). Severe post‐thoracotomy pain can result from pleural (lung lining) …

Effect of regional vs general anesthesia on incidence of postoperative delirium in older patients undergoing hip fracture surgery: the RAGA randomized trial

…, T Melody, S Jin, Y Yao, J Wu, J Chen, FG Smith… - Jama, 2022 - jamanetwork.com
Importance In adults undergoing hip fracture surgery, regional anesthesia may reduce
postoperative delirium, but there is uncertainty about its effectiveness. Objective To investigate, in …

[HTML][HTML] Effect of intravenous β-2 agonist treatment on clinical outcomes in acute respiratory distress syndrome (BALTI-2): a multicentre, randomised controlled trial

FG Smith, GD Perkins, S Gates, D Young, DF McAuley… - The Lancet, 2012 - thelancet.com
Background In a previous randomised controlled phase 2 trial, intravenous infusion of
salbutamol for up to 7 days in patients with acute respiratory distress syndrome (ARDS) reduced …

Resolvin D1 stimulates alveolar fluid clearance through alveolar epithelial sodium channel, Na, K-ATPase via ALX/cAMP/PI3K pathway in lipopolysaccharide-induced …

…, H Li, Y Hao, Y Gao, LM Yang, FG Smith… - The Journal of …, 2014 - journals.aai.org
Resolvin D1 (7S, 8R, 17S-trihydroxy-4Z, 9E, 11E, 13Z, 15E, 19Z-docosahexaenoic acid)(RvD1),
generated from ω-3 fatty docosahexaenoic acids, is believed to exert anti-inflammatory …

[HTML][HTML] High generation of reactive oxygen species from neutrophils in patients with severe COVID-19

…, H Martin, M Le Breuilly, T Whitehouse, F Gao-Smith… - Scientific reports, 2022 - nature.com
Neutrophilia and an elevated neutrophil:lymphocyte ratio are both characteristic features of
severe COVID-19 infection. However, functional neutrophil responses have been poorly …

[HTML][HTML] Vitamin D attenuates lung injury via stimulating epithelial repair, reducing epithelial cell apoptosis and inhibits TGF-β induced epithelial to mesenchymal …

…, Q Wang, RCA Dancer, D Parekh, F Gao-Smith… - Biochemical …, 2020 - Elsevier
Vitamin D regulates cell proliferation, inhibits cytokines release at sites of inflammation and
reduces inflammatory responses. In this study, the aim was to investigate whether …

Pravastatin for early‐onset pre‐eclampsia: a randomised, blinded, placebo‐controlled trial

…, J Rennie, J Peacock, F Gao Smith… - … Journal of Obstetrics …, 2020 - Wiley Online Library
Objective Women with pre‐eclampsia have elevated circulating levels of soluble fms‐like
tyrosine kinase‐1 (sFlt‐1). Statins can reduce sFlt‐1 from cultured cells and improve …

[HTML][HTML] Namilumab or infliximab compared with standard of care in hospitalised patients with COVID-19 (CATALYST): a randomised, multicentre, multi-arm …

…, S Bowden, M Bangash, F Gao-Smith… - The Lancet …, 2022 - thelancet.com
Background Dysregulated inflammation is associated with poor outcomes in COVID-19. We
aimed to assess the efficacy of namilumab (a granulocyte-macrophage colony stimulating …

Acute respiratory distress syndrome subphenotypes and differential response to simvastatin: secondary analysis of a randomised controlled trial

…, R Bennett, V Martinson, L Sleight, N Smith… - The Lancet …, 2018 - thelancet.com
Background Precision medicine approaches that target patients on the basis of disease
subtype have transformed treatment approaches to cancer, asthma, and other heterogeneous …

[HTML][HTML] Neutrophil extracellular trap production in patients with colorectal cancer in vitro

JJR Richardson, C Hendrickse, F Gao-Smith… - International journal of …, 2017 - hindawi.com
Purpose. Neutrophil Extracellular Traps (NETs) are extracellular neutrophil derived DNA webs
which have been implicated in cancer progression and in the development of metastases. …