Continuous nitric oxide synthesis by inducible nitric oxide synthase in normal human airway epithelium in vivo.
…, TW Rice, DJ Stuehr, FB Thunnissen… - Proceedings of the …, 1995 - National Acad Sciences
Nitric oxide (NO) is an important mediator of inflammatory responses in the lung and a key
regulator of bronchomotor tone. An airway NO synthase (NOS; EC 1.14.13.39) has been …
regulator of bronchomotor tone. An airway NO synthase (NOS; EC 1.14.13.39) has been …
[HTML][HTML] Acetylcholine receptor pathway and lung cancer
FB Thunnissen - Journal of Thoracic Oncology, 2009 - Elsevier
Genome-wide association studies revealed chromosome regions 15q24-25 were associated
with a higher risk for development of lung cancer. The 15q24-25 region encompasses the …
with a higher risk for development of lung cancer. The 15q24-25 region encompasses the …
Interferon gamma and interleukin 4 stimulate prolonged expression of inducible nitric oxide synthase in human airway epithelium through synthesis of soluble …
…, RA Dweik, FB Thunnissen… - The Journal of …, 1997 - Am Soc Clin Investig
Human respiratory epithelium expresses inducible nitric oxide synthase (iNOS) continuously
in vivo, however mechanisms responsible for maintenance of expression are not known. …
in vivo, however mechanisms responsible for maintenance of expression are not known. …
Decreased Cu, Zn-SOD activity in asthmatic airway epithelium: correction by inhaled corticosteroid in vivo
HR De Raeve, FB Thunnissen… - … of Physiology-Lung …, 1997 - journals.physiology.org
To investigate the antioxidant response of respiratory epithelium to the chronic airway
inflammation in asthma, the major intracellular antioxidants [copper and zinc-containing …
inflammation in asthma, the major intracellular antioxidants [copper and zinc-containing …
Number and proliferation of neuroendocrine cells in normal human airway epithelium.
…, J Koudstaal, JW Arends, FB Thunnissen - American journal of …, 1996 - atsjournals.org
Pulmonary neuroendocrine cells (PNECs) are ubiquitous in human adult airway epithelium,
and are implicated in pulmonary disease as PNEC hyperplasia has been described in a …
and are implicated in pulmonary disease as PNEC hyperplasia has been described in a …
[HTML][HTML] EGFR and KRAS mutations in lung carcinomas in the Dutch population: increased EGFR mutation frequency in malignant pleural effusion of lung …
…, MJL Ligtenberg, FB Thunnissen… - Cellular oncology, 2012 - Springer
Background Frequencies of EGFR and KRAS mutations in non-small cell lung cancer (NSCLC)
have predominantly been determined in East Asian and North American populations, …
have predominantly been determined in East Asian and North American populations, …
Retreatment with erlotinib: regain of TKI sensitivity following a drug holiday for patients with NSCLC who initially responded to EGFR-TKI treatment
…, L Crombag, DAM Heideman, FB Thunnissen… - European journal of …, 2011 - Elsevier
BACKGROUND: Tyrosine kinase inhibitors (TKI) of the epidermal growth factor receptor (EGFR)
are approved as treatment of non-small-cell lung cancer (NSCLC). Despite an initially …
are approved as treatment of non-small-cell lung cancer (NSCLC). Despite an initially …
Cytoglobin, the newest member of the globin family, functions as a tumor suppressor gene
…, L Girard, Y Xie, C Prinsen, FB Thunnissen… - Cancer research, 2008 - AACR
Cytoglobin (CYGB) is a recently discovered vertebrate globin distantly related to myoglobin
with unknown function. CYGB is assigned to chromosomal region 17q25, which is frequently …
with unknown function. CYGB is assigned to chromosomal region 17q25, which is frequently …
Application of a methylation gene panel by quantitative PCR for lung cancers
Detection of lung cancer at early stages could potentially increase survival rates. One
promising approach is the application of suitable lung cancer-specific biomarkers to specimens …
promising approach is the application of suitable lung cancer-specific biomarkers to specimens …
Can the Memorial Sloan-Kettering Cancer Center nomogram predict the likelihood of nonsentinel lymph node metastases in breast cancer patients in the Netherlands …
…, DM Kuster, GJ van der Wilt, FB Thunnissen… - Annals of surgical …, 2005 - Springer
Background According to Dutch guidelines, an axillary lymph node dissection (ALND) is
recommended whenever a sentinel lymph node (SLN) contains metastatic disease. However, …
recommended whenever a sentinel lymph node (SLN) contains metastatic disease. However, …