Genetics and genomics of pulmonary arterial hypertension
…, JE Loyd, JH Newman, JA Phillips III, F Soubrier… - Journal of the American …, 2009 - jacc.org
Pulmonary arterial hypertension (PAH) is a rare disorder that may be hereditable (HPAH),
idiopathic (IPAH), or associated with either drug-toxin exposures or other medical conditions. …
idiopathic (IPAH), or associated with either drug-toxin exposures or other medical conditions. …
Genetics and genomics of pulmonary arterial hypertension
Major discoveries have been obtained within the last decade in the field of hereditary
predisposition to pulmonary arterial hypertension (PAH). Among them, the identification of bone …
predisposition to pulmonary arterial hypertension (PAH). Among them, the identification of bone …
Genetics and genomics of pulmonary arterial hypertension
…, CG Elliott, WC Nichols, F Soubrier… - European …, 2019 - Eur Respiratory Soc
Since 2000 there have been major advances in our understanding of the genetic and
genomics of pulmonary arterial hypertension (PAH), although there remains much to discover. …
genomics of pulmonary arterial hypertension (PAH), although there remains much to discover. …
An insertion/deletion polymorphism in the angiotensin I-converting enzyme gene accounting for half the variance of serum enzyme levels.
…, F Cambien, P Corvol, F Soubrier - The Journal of …, 1990 - Am Soc Clin Investig
A polymorphism consisting of the presence or absence of a 250-bp DNA fragment was
detected within the angiotensin I-converting enzyme gene (ACE) using the endothelial ACE …
detected within the angiotensin I-converting enzyme gene (ACE) using the endothelial ACE …
Deletion polymorphism in the gene for angiotensin-converting enzyme is a potent risk factor for myocardial infarction
…, L Tiret, P Amouyel, F Alhenc-Gelas, F Soubrier - Nature, 1992 - nature.com
FACTORS involved in the pathogenesis of atherosclerosis, thrombosis and vasoconstriction
1,2 contribute to the development of coronary heart disease. In a study comparing patients …
1,2 contribute to the development of coronary heart disease. In a study comparing patients …
Evidence, from combined segregation and linkage analysis, that a variant of the angiotensin I-converting enzyme (ACE) gene controls plasma ACE levels.
…, C Breda, P Corvol, F Cambien, F Soubrier - American journal of …, 1992 - ncbi.nlm.nih.gov
The hypothesis of a genetic control of plasma angiotensin I-converting enzyme (ACE) level
has been suggested both by segregation analysis and by the identification of an insertion/…
has been suggested both by segregation analysis and by the identification of an insertion/…
Molecular basis of human hypertension: role of angiotensinogen
… enzyme, and histocompatibility leukocyte antigen (Soubrier … This conclusion is further
strengthened by the results of another study (F. Soubrier et al., unpublished data), where M235T …
strengthened by the results of another study (F. Soubrier et al., unpublished data), where M235T …
Protective role of interleukin-10 in atherosclerosis
…, F Emmanuel, MF Bureau, F Soubrier… - Circulation …, 1999 - Am Heart Assoc
The potential role of anti-inflammatory cytokines in the modulation of the atherosclerotic
process remains unknown. Interleukin (IL)-10 has potent deactivating properties in …
process remains unknown. Interleukin (IL)-10 has potent deactivating properties in …
PCR detection of the insertion/deletion polymorphism of the human angiotensin converting enzyme gene (DCP1)(dipeptidyl carboxypeptidase 1)
B Rigat, C Hubert, P Corvol, F Soubrier - Nucleic acids research, 1992 - ncbi.nlm.nih.gov
Albinism is an inherited, generalised hypomelanotic condition, caused by impaired melanin
synthesis (1). Tyrosinase catalyses the conversion of tyrosine into melanin. Mutations in its …
synthesis (1). Tyrosinase catalyses the conversion of tyrosine into melanin. Mutations in its …
Angiotensin II type 1 receptor gene polymorphisms in human essential hypertension.
…, E Clauser, L Tiret, F Cambien, P Corvol, F Soubrier - …, 1994 - Am Heart Assoc
We conducted the present study to determine whether the angiotensin II type I receptor (AT1)
gene might be implicated in human essential hypertension by using case-control and …
gene might be implicated in human essential hypertension by using case-control and …