Three hundred thirty-one cases of brucellosis included in a 10-year prospective protocol
were reviewed to identify and follow up patients with spondylitis. Of 20 patients (17 male and …

Background Penicillin-resistant strains of Streptococcus pneumoniae are now found
worldwide, and strains with resistance to cephalosporin are being reported. The appropriate …

This review addresses selected aspects of the management of severe healthcare-associated
infections due to methicillin-resistant Staphylococcus aureus (MRSA), including the …

Beta-lactam drugs, whose mechanism of action is inhibition of the last stage of bacterial cell
wall synthesis, are the largest family of antimicrobial agents and the most widely used in …

Beginning in 1992, a sustained outbreak of multiresistantAcinetobacter baumannii infections
was noted in our 1,000-bed hospital in Barcelona, Spain, resulting in considerable overuse …

Background Reverse-transcriptase inhibitors have only moderate clinical efficacy against
the human immunodeficiency virus type 1 (HIV-1). Ritonavir is an inhibitor of HIV-1 protease …

Background Health care–associated pneumonia (HCAP) has been proposed as a new
category of respiratory infection. However, limited data exist to validate this entity. We aimed to …

An outbreak due to extended-spectrum β-lactamase-producingKlebsiella pneumoniae (ESBL-KP)
was detected from May 1993 to June 1995. A total of 145 patients, particularly patients …

Background Early failure is a matter of great concern in the treatment of community-acquired
pneumonia. However, information on its causes and risk factors is lacking. Methods …

We performed an observational analysis of pro-spectively collected data on 1,474 adult
patients who were hospitalized for community-acquired pneumonia; 1,169 patients were under …