Absorption, metabolism, and excretion of14C-labeled Tapentadol HCl in healthy male subjects
R Terlinden, J Ossig, F Fliegert, C Lange… - European journal of drug …, 2007 - Springer
Tapentadol is a novel, centrally acting oral analgesic with a dual mode of action that has
demonstrated efficacy in preclinical and clinical models of pain relief. The present study …
demonstrated efficacy in preclinical and clinical models of pain relief. The present study …
Hematopoietic stem and progenitor cell mobilization in mice and humans by a first‐in‐class mirror‐image oligonucleotide inhibitor of CXCL12
…, M Humphrey, S Klussmann, F Fliegert - Clinical …, 2013 - Wiley Online Library
NOX‐A12 is a PEGylated mirror‐image oligonucleotide (a so‐called Spiegelmer) that binds
to CXCL12 (stromal cell–derived factor‐1, SDF‐1) with high affinity thereby inhibiting …
to CXCL12 (stromal cell–derived factor‐1, SDF‐1) with high affinity thereby inhibiting …
The effects of tramadol on static and dynamic pupillometry in healthy subjects—the relationship between pharmacodynamics, pharmacokinetics and CYP2D6 …
F Fliegert, B Kurth, K Göhler - European journal of clinical pharmacology, 2005 - Springer
Objectives The main objective of the present study was to provide information on whether
static and dynamic pupillometry can be used for pharmacodynamic profiling, particularly when …
static and dynamic pupillometry can be used for pharmacodynamic profiling, particularly when …
[HTML][HTML] ADP-ribosylation factor (ARF)-like 4, 6, and 7 represent a subgroup of the ARF family characterized by rapid nucleotide exchange and a nuclear localization …
S Jacobs, C Schilf, F Fliegert, S Koling, Y Weber… - FEBS letters, 1999 - Elsevier
The novel ARF-like GTPase ARL7 is a close relative of ARL4 and ARL6 (71% and 59% identical
amino acids). A striking characteristic of these GTPases is their basic C-terminus which, …
amino acids). A striking characteristic of these GTPases is their basic C-terminus which, …
Comparative analysis of the frequency of house dust mite specific and nonspecific Th1 and Th2 cells in skin lesions and peripheral blood of patients with atopic …
…, C Gutgesell, F Fliegert, R Bonifer, F Herrmann - Journal of molecular …, 1996 - Springer
Until recently it was believed that the T cell response of atopic dermatitis patients challenged
with inhalant allergens originates almost exclusively and specifically from Th2 cells capable …
with inhalant allergens originates almost exclusively and specifically from Th2 cells capable …
Safety, Tolerability, and Pharmacokinetics of IMU‐935, a Novel Inverse Agonist of Retinoic Acid Receptor–Related Orphan Nuclear Receptor γt: Results From a …
…, M Marolt, H Kohlhof, D Vitt, F Fliegert… - Clinical …, 2023 - Wiley Online Library
Retinoic acid receptor–related orphan nuclear receptor (ROR)γt regulates the transcription
of interleukin‐17 and other cytokines implicated in inflammatory and autoimmune diseases. …
of interleukin‐17 and other cytokines implicated in inflammatory and autoimmune diseases. …
[HTML][HTML] The ADP-ribosylation factor (ARF)-related GTPase ARF-related protein binds to the ARF-specific guanine nucleotide exchange factor cytohesin and inhibits …
…, M Schmidt, M Asmus, S Bayer, F Fliegert… - Journal of Biological …, 1999 - ASBMB
… Frank Fliegert Frank Fliegert … HEK-293 cells overexpressing M 3 receptors were grown
in Dulbecco's modified Eagle's medium/F-12 medium as described previously ( …
in Dulbecco's modified Eagle's medium/F-12 medium as described previously ( …
Comparison of lymphocyte subsets, monocytes, and NK cells in three different lung compartments and peripheral blood in the rat
FG Fliegert, T Tschernig, R Pabst - Experimental lung research, 1996 - Taylor & Francis
… The total recovered BAL contained 7.7 f 2.2 X lo6 leukocytes/total recovered lavage volume.
Mechanical disruption of lung tissue yielded a significantly (p < .05) higher total of cells than …
Mechanical disruption of lung tissue yielded a significantly (p < .05) higher total of cells than …
(689): Pharmacokinetics, excretion, and metabolism of tapentadol HCl, a novel centrally acting analgesic, in healthy subjects
R Terlinden, J Ossig, F Fliegert, K Gohler - The Journal of Pain, 2006 - jpain.org
Tapentadol HCl is a centrally acting oral analgesic with a dual mechanism of action of μ-opioid
agonist and norepinephrine reuptake inhibition. Serum pharmacokinetics of tapentadol …
agonist and norepinephrine reuptake inhibition. Serum pharmacokinetics of tapentadol …
Randomized double-blind placebo-controlled PK/PD study on the effects of a single intravenous dose of the anti-hepcidin Spiegelmer NOX-H94 on serum iron during …
…, DW Swinkels, A John, F Schwoebel, F Fliegert… - Critical Care, 2013 - Springer
Methods A randomized, double-blind, placebo-controlled trial in 24 healthy young men. At T=
0 hours, 2 ng/kg E. coli endotoxin was administered intravenously (iv), followed by 1.2 mg/…
0 hours, 2 ng/kg E. coli endotoxin was administered intravenously (iv), followed by 1.2 mg/…