Clara cell secretory protein (CC16): features as a peripheral lung biomarker

F Broeckaert, A Clippe, B Knoops… - Annals of the New …, 2000 - Wiley Online Library
Clara cell protein (CC16 or CC10) is a 15.8‐kDa protein secreted all along the tracheobronchial
tree and especially in the terminal bronchioles where Clara cells are localized. Even …

The Belgian PCB/dioxin incident: analysis of the food chain contamination and health risk evaluation

A Bernard, F Broeckaert, G De Poorter, A De Cock… - Environmental …, 2002 - Elsevier
The Belgian PCB incident occurred at the end of January 1999 when a mixture of
polychlorinated biphenyls (PCBs) contaminated with dioxins was accidentally added to a stock of …

Food contamination by PCBs and dioxins

A Bernard, C Hermans, F Broeckaert, G De Poorter… - Nature, 1999 - nature.com
In February 1999, a poisoning episode broke out in several poultry farms in Belgium. The
Belgian authorities took immediate safeguards to protect public health and implemented a …

Rapid HCV-RNA decline with once daily TMC435: a phase I study in healthy volunteers and hepatitis C patients

…, K Mariën, P Van Remoortere, H de Kock, F Broeckaert… - Gastroenterology, 2010 - Elsevier
BACKGROUND & AIMS: The search for targeted anti-hepatitis C virus (HCV) drugs is driven
by the adverse effect profile and limited efficacy of the current standard of care (pegylated …

Serum clara cell protein: a sensitive biomarker of increased lung epithelium permeability caused by ambient ozone.

F Broeckaert, K Arsalane, C Hermans… - Environmental …, 2000 - ehp.niehs.nih.gov
… E-mail: broeckaert@toxi.ucl.ac.be This study was supported by the European Union
Environment and Climate program (CT96-0171) and the Program on Sustainable Development of …

Clara cell specific protein (CC16) expression after acute lung inflammation induced by intratracheal lipopolysaccharide administration

K ARSALANE, F BROECKAERT, B Knoops… - American journal of …, 2000 - atsjournals.org
Clara cell secretory protein (CC16, CC10, or CCSP), the major secretory protein of the
Clara cell, presents several biologic properties, suggesting that it may play a protective role …

Polymorphism of quinone-metabolizing enzymes and susceptibility to ozone-induced acute effects

…, S Vanni, MV Vettori, F Broeckaert… - American journal of …, 2001 - atsjournals.org
The role of the genetic polymorphism of NAD(P)H:quinone oxidoreductase (NQO1) and
glutathione-S-transferase μ -1 (GSTM1) in the responsiveness to O 3 -induced acute effects was …

Lung epithelial damage at low concentrations of ambient ozone

F Broeckaert, K Arsalane, C Hermans, E Bergamaschi… - The Lancet, 1999 - thelancet.com
The cyclooxygenase (COX) step is rate-limiting in prostaglandin biosynthesis. 1 COX exists
in two isoforms: COX-1 and COX-2. COX-1 is constitutively expressed in most cells and …

Quantification of Clara cell protein in rat and mouse biological fluids using a sensitive immunoassay

T Halatek, C Hermans, F Broeckaert… - European …, 1998 - Eur Respiratory Soc
Clara cell protein is a 16-17 kDa protein (CC16) secreted by Clara cells in the bronchiolar
lining fluid of the lung. In order to investigate the potential of this protein as a pulmonary …

Science based guidance for the assessment of endocrine disrupting properties of chemicals

R Bars, F Broeckaert, I Fegert, M Gross… - Regulatory Toxicology …, 2011 - Elsevier
… Author links open overlay panel Remi Bars a , Fabrice Broeckaert b , Ivana Fegert c ,
Melanie Gross d , Nina Hallmark e , Tim Kedwards f , Dick Lewis g , Sue O’Hagan h , Grace H. …