MALAT-1, a novel noncoding RNA, and thymosin β4 predict metastasis and survival in early-stage non-small cell lung cancer

…, PM Schneider, N Tidow, B Brandt, H Buerger, E Bulk… - Oncogene, 2003 - nature.com
Early-stage non-small cell lung cancer (NSCLC) can be cured by surgical resection, but a
substantial fraction of patients ultimately dies due to distant metastasis. In this study, we used …

Mechanosensitive ion channels push cancer progression

Z Pethő, K Najder, E Bulk, A Schwab - Cell Calcium, 2019 - Elsevier
In many cases, the mechanical properties of a tumor are different from those of the host
tissue. Mechanical cues regulate cancer development by affecting both tumor cells and their …

[HTML][HTML] The long noncoding MALAT-1 RNA indicates a poor prognosis in non-small cell lung cancer and induces migration and tumor growth

…, S Koschmieder, J Humberg, D Jungen, E Bulk… - Journal of thoracic …, 2011 - Elsevier
Introduction: The functions of large noncoding RNAs (ncRNAs) have remained elusive in
many cases. Metastasis-Associated-in-Lung-Adenocarcinoma-Transcript-1 (MALAT-1) is an …

[HTML][HTML] The role of TRP channels in the metastatic cascade

B Fels, E Bulk, Z Pethő, A Schwab - Pharmaceuticals, 2018 - mdpi.com
A dysregulated cellular Ca 2+ homeostasis is involved in multiple pathologies including
cancer. Changes in Ca 2+ signaling caused by altered fluxes through ion channels and …

[HTML][HTML] pH-channeling in cancer: how pH-dependence of cation channels shapes cancer pathophysiology

…, T Carvalho, R McMorrow, LM Todesca, M Rugi, E Bulk… - Cancers, 2020 - mdpi.com
Tissue acidosis plays a pivotal role in tumor progression: in particular, interstitial acidosis
promotes tumor cell invasion, and is a major contributor to the dysregulation of tumor immunity …

S100 family members and trypsinogens are predictors of distant metastasis and survival in early-stage non-small cell lung cancer

S Diederichs, E Bulk, B Steffen, P Ji, L Tickenbrock… - Cancer research, 2004 - AACR
Distant metastasis is the predominant cause of death in early-stage non-small cell lung cancer
(NSCLC). Currently, it is impossible to predict the occurrence of metastasis at early stages …

Identification of metastasis-associated receptor tyrosine kinases in non–small cell lung cancer

C Müller-Tidow, S Diederichs, E Bulk, T Pohle… - Cancer research, 2005 - AACR
Abstract Development of distant metastasis after tumor resection is the leading cause of death
in early-stage non–small cell lung cancer (NSCLC). Receptor tyrosine kinases (RTK) are …

S100A2 induces metastasis in non–small cell lung cancer

E Bulk, B Sargin, U Krug, A Hascher, Y Jun… - Clinical Cancer …, 2009 - AACR
Purpose: S100 proteins are implicated in metastasis development in several cancers. In this
study, we analyzed the prognostic role of mRNA levels of all S100 proteins in early stage …

Epigenetic dysregulation of KCa3.1 channels induces poor prognosis in lung cancer

E Bulk, AS Ay, M Hammadi… - … journal of cancer, 2015 - Wiley Online Library
Epigenomic changes are an important feature of malignant tumors. How tumor aggressiveness
is affected by DNA methylation of specific loci is largely unexplored. In genome‐wide …

The EPHB6 receptor tyrosine kinase is a metastasis suppressor that is frequently silenced by promoter DNA hypermethylation in non–small cell lung cancer

J Yu, E Bulk, P Ji, A Hascher, M Tang, R Metzger… - Clinical Cancer …, 2010 - AACR
Purpose: Loss of EPHB6 receptor tyrosine kinase expression in early-stage non–small cell
lung carcinoma (NSCLC) is associated with the subsequent development of distant …