Background Mortality rates are high among hospitalized patients with COVID-19, especially
in those intubated on the ICU. Insight in pathways associated with unfavourable outcome …

Severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) is the causative agent of
the current coronavirus disease 2019 (COVID‐19) pandemic. Understanding the immune …

A subgroup of patients with idiopathic pulmonary arterial hypertension (IPAH) has severely
reduced diffusing capacity of the lung for carbon monoxide (D LCO ) and poor prognosis. …

Purpose Definitive treatment for patients with early-stage non-small cell lung cancer (ES-NSCLC)
is usually well tolerated. Patients with ES-NSCLC and coexisting interstitial lung …

Background Knowledge of the pathophysiology of COVID-19 is almost exclusively derived
from studies that examined the immune response in blood. We here aimed to analyse the …

Background The major complication of COVID-19 is hypoxaemic respiratory failure from
capillary leak and alveolar oedema. Experimental and early clinical data suggest that the …

Monocytes are antigen-presenting cells (APCs) that play diverse roles in promoting or
regulating inflammatory responses, but their role in T cell stimulation is not well defined. In …

Importance: Among COVID-19 cases, especially the (frail) elderly show a high number of
severe infections, hospital admissions, complications, and death. The highest mortality is found …

COVID‐19 is a pandemic with high morbidity and mortality. In an autopsy cohort of COVID‐19
patients, we found extensive accumulation of the tryptophan degradation products 3‐…

Rationale Systemic activation of procoagulant and inflammatory mechanisms has been
implicated in the pathogenesis of COVID-19. Knowledge of activation of these host response …