Mitochondria supply cells with energy in the form of ATP, guide apoptosis, and contribute to
calcium buffering and reactive oxygen species production. To support these diverse functions…

Transpulmonary pressure and the mechanical stresses of breathing modulate many essential
cell functions in the lung via mechanotransduction. We review how mechanical factors …

Secretion of pulmonary surfactant that maintains low surface tension within the lung is
primarily mediated by mechanical stretching of alveolar epithelial type II (AEII) cells. We have …

Cells in the body are exposed to irregular mechanical stimuli. Here, we review the so-called
fluctuation-driven mechanotransduction in which stresses stretching cells vary on a cycle-by-…

Cells can be exposed to irregular mechanical fluctuations, such as those arising from changes
in blood pressure. Here, we report that ATP production, assessed through changes in …

In pulmonary emphysema, the alveolar structure progressively breaks down via a three-dimensional
(3D) process that leads to airspace enlargement. The characterization of such …

Emphysema is a progressive disease characterized by the destruction of peripheral airspaces
and subsequent decline in lung function. However, the relation between structure and …

Pulmonary emphysema is one of the distinct pathological forms of chronic obstructive pulmonary
disease (COPD) that is accompanied by gradual elimination of alveolar tissue, causing …

The accepted protocol to ventilate patients with acute lung injury is to use low tidal volume (V
T ) in combination with recruitment maneuvers or positive end-expiratory pressure (PEEP). …

Most tissues in the body are under mechanical tension, and while enzymes mediate many
cellular and extracellular processes, the effects of mechanical forces on enzyme reactions in …