JAK2 mediates lung fibrosis, pulmonary vascular remodelling and hypertension in idiopathic pulmonary fibrosis: an experimental study

…, F Perez-Vizcaino, A Cogolludo, E Pastor, E Artigues… - Thorax, 2018 - thorax.bmj.com
Background Pulmonary hypertension (PH) is a common disorder in patients with idiopathic
pulmonary fibrosis (IPF) and portends a poor prognosis. Recent studies using vasodilators …

[HTML][HTML] IL-11 system participates in pulmonary artery remodeling and hypertension in pulmonary fibrosis

J Milara, I Roger, P Montero, E Artigues, J Escrivá… - Respiratory …, 2022 - Springer
Background Pulmonary hypertension (PH) associated to idiopathic pulmonary fibrosis (IPF)
portends a poor prognosis. IL-11 has been implicated in fibrotic diseases, but their role on …

Aclidinium inhibits cigarette smoke-induced lung fibroblast-to-myofibroblast transition

J Milara, A Serrano, T Peiró, E Artigues… - European …, 2013 - Eur Respiratory Soc
Cigarette smoking contributes to lung remodelling in chronic obstructive pulmonary disease
(COPD). As part of this remodelling, peribronchiolar fibrosis is observed in the small airways …

Vascular effects of sildenafil in patients with pulmonary fibrosis and pulmonary hypertension: an ex vivo/in vitro study

…, J Escrivá, JL Ortiz, G Juan, E Artigues… - European …, 2016 - Eur Respiratory Soc
Sildenafil improves the 6-min walking distance in patients with idiopathic pulmonary fibrosis
(IPF) and right-sided ventricular systolic dysfunction. We analysed the previously …

Mucin 1 deficiency mediates corticosteroid insensitivity in asthma

J Milara, A Morell, A de Diego, E Artigues, E Morcillo… - Allergy, 2019 - Wiley Online Library
Background The loss of corticosteroid efficacy is an important issue in severe asthma
management and may lead to poor asthma control and deterioration of airflow. Recent data …

MUC4 is overexpressed in idiopathic pulmonary fibrosis and collaborates with transforming growth factor β inducing fibrotic responses

J Milara, B Ballester, MJ Safont, E Artigues… - Mucosal …, 2021 - nature.com
Several mucins are implicated in idiopathic pulmonary fibrosis (IPF); however, there is no
evidence regarding the role of MUC4 in the development of IPF. Here we demonstrated that …

MUC1 intracellular bioactivation mediates lung fibrosis

J Milara, B Ballester, P Montero, J Escriva, E Artigues… - Thorax, 2020 - thorax.bmj.com
Background Serum KL6/mucin 1 (MUC1) has been identified as a potential biomarker in
idiopathic pulmonary fibrosis (IPF), but the role of MUC1 intracellular bioactivation in IPF is …

Simvastatin increases the ability of roflumilast N-oxide to inhibit cigarette smoke-induced epithelial to mesenchymal transition in well-differentiated human bronchial …

J Milara, T Peiró, A Serrano, E Artigues… - COPD: Journal of …, 2015 - Taylor & Francis
Background: Cigarette smoking contributes to epithelial-mesenchymal transition (EMT) in
COPD small bronchi as part of the lung remodeling process. We recently observed that …

[HTML][HTML] Targeting IL-11 system as a treatment of pulmonary arterial hypertension

J Milara, I Roger, P Montero, E Artigues… - Pharmacological …, 2023 - Elsevier
IL-11 is linked to fibrotic diseases, but its role in pulmonary hypertension is unclear. We
examined IL-11's involvement in idiopathic pulmonary arterial hypertension (iPAH). Using …

Exocrine pancreatic changes following acute attack of biliary pancreatitis

E Pareja, E Artigues, L Aparisi, R Fabra, V Martínez… - Pancreatology, 2002 - Elsevier
Following the Cambridge and Marseilles Symposia, functional recovery of the pancreas
occurs if the primary cause and complications of the disease have been eliminated. However, …