A new era for cancer treatment: gold‐nanoparticle‐mediated thermal therapies
Nanotechnology‐based cancer treatment approaches potentially provide localized, targeted
therapies that aim to enhance efficacy, reduce side effects, and improve patient quality of life…
therapies that aim to enhance efficacy, reduce side effects, and improve patient quality of life…
Immunonanoshells for targeted photothermal ablation of tumor cells
Consisting of a silica core surrounded by a thin gold shell, nanoshells possess an optical
tunability that spans the visible to the near infrared (NIR) region, a region where light …
tunability that spans the visible to the near infrared (NIR) region, a region where light …
[HTML][HTML] Cancer cell membrane-coated nanoparticles for cancer management
Cancer is a global health problem in need of transformative treatment solutions for improved
patient outcomes. Many conventional treatments prove ineffective and produce undesirable …
patient outcomes. Many conventional treatments prove ineffective and produce undesirable …
Spherical nucleic acid nanoparticle conjugates as an RNAi-based therapy for glioblastoma
Glioblastoma multiforme (GBM) is a neurologically debilitating disease that culminates in
death 14 to 16 months after diagnosis. An incomplete understanding of how cataloged genetic …
death 14 to 16 months after diagnosis. An incomplete understanding of how cataloged genetic …
Salsalate (salicylate) uncouples mitochondria, improves glucose homeostasis, and reduces liver lipids independent of AMPK-β1
Salsalate is a prodrug of salicylate that lowers blood glucose in patients with type 2 diabetes
(T2D) and reduces nonalcoholic fatty liver disease (NAFLD) in animal models; however, the …
(T2D) and reduces nonalcoholic fatty liver disease (NAFLD) in animal models; however, the …
Gold nanoparticle‐mediated photothermal therapy: applications and opportunities for multimodal cancer treatment
Photothermal therapy ( PTT ), in which nanoparticles embedded within tumors generate
heat in response to exogenously applied laser light, has been well documented as an …
heat in response to exogenously applied laser light, has been well documented as an …
Advances in targeted nanotherapeutics: from bioconjugation to biomimicry
Since the emergence of cancer nanomedicine, researchers have had intense interest in
developing nanoparticles (NPs) that can specifically target diseased sites while avoiding …
developing nanoparticles (NPs) that can specifically target diseased sites while avoiding …
GDF15: emerging biology and therapeutic applications for obesity and cardiometabolic disease
Growth differentiation factor 15 (GDF15) is a member of the TGFβ superfamily whose
expression is increased in response to cellular stress and disease as well as by metformin. …
expression is increased in response to cellular stress and disease as well as by metformin. …
Elucidating the fundamental mechanisms of cell death triggered by photothermal therapy
JR Melamed, RS Edelstein, ES Day - ACS nano, 2015 - ACS Publications
Photothermal therapy (PTT) utilizes nanoparticles embedded within tumors as exogenous
energy absorbers to convert laser light energy into heat to ablate cancer cells. While PTT is a …
energy absorbers to convert laser light energy into heat to ablate cancer cells. While PTT is a …
AMPK as a therapeutic target for treating metabolic diseases
EA Day, RJ Ford, GR Steinberg - Trends in Endocrinology & Metabolism, 2017 - cell.com
The AMP-activated protein kinase (AMPK) is a central regulator of multiple metabolic
pathways and may have therapeutic importance for treating obesity, insulin resistance, type 2 …
pathways and may have therapeutic importance for treating obesity, insulin resistance, type 2 …