User profiles for Emilie Roudier
 | Emilie RoudierAssistant professor, School of Kinesiology and Health Science, Faculty of Health,York … Verified email at yorku.ca Cited by 1118 |
Statins induce mammalian target of rapamycin (mTOR)-mediated inhibition of Akt signaling and sensitize p53-deficient cells to cytostatic drugs
Cholesterol-lowering statins have been shown to have anticancer effects in different models
and sensitize human tumor cells to cytostatic drugs. We have investigated the effect of …
and sensitize human tumor cells to cytostatic drugs. We have investigated the effect of …
[HTML][HTML] MEK-ERK-mediated phosphorylation of Mdm2 at Ser-166 in hepatocytes: Mdm2 is activated in response to inhibited Akt signaling
Mdm2 inactivates the tumor suppressor p53 and Akt has been shown to be a major activator
of Mdm2 in many cell types. We have investigated the regulation of Mdm2 in hepatocytes. …
of Mdm2 in many cell types. We have investigated the regulation of Mdm2 in hepatocytes. …
Angio‐adaptation in unloaded skeletal muscle: new insights into an early and muscle type‐specific dynamic process
With a remarkable plasticity, skeletal muscle adapts to an altered functional demand.
Muscle angio‐adaptation can either involve the growth or the regression of capillaries as …
Muscle angio‐adaptation can either involve the growth or the regression of capillaries as …
Endothelial-specific FoxO1 depletion prevents obesity-related disorders by increasing vascular metabolism and growth
10.7554/eLife.39780.001 Impaired angiogenesis is a hallmark of metabolically dysfunctional
adipose tissue in obesity. However, the underlying mechanisms restricting angiogenesis …
adipose tissue in obesity. However, the underlying mechanisms restricting angiogenesis …
[HTML][HTML] Identification of a mechanism underlying regulation of the anti-angiogenic forkhead transcription factor FoxO1 in cultured endothelial cells and ischemic …
M Milkiewicz, E Roudier, JL Doyle, A Trifonova… - The American Journal of …, 2011 - Elsevier
Chronic limb ischemia, a complication commonly observed in conjunction with cardiovascular
disease, is characterized by insufficient neovascularization despite the up-regulation of pro…
disease, is characterized by insufficient neovascularization despite the up-regulation of pro…
[HTML][HTML] Female mice have higher angiogenesis in perigonadal adipose tissue than males in response to high-fat diet
…, O Rezvan, E Nwadozi, E Roudier… - Frontiers in …, 2018 - frontiersin.org
Background: Impaired capillary growth (angiogenesis) in skeletal muscle and adipose tissue
contributes to the development of metabolic disorders in obese males. This association …
contributes to the development of metabolic disorders in obese males. This association …
Forkhead BoxO transcription factors restrain exercise‐induced angiogenesis
D Slopack, E Roudier, STK Liu… - The Journal of …, 2014 - Wiley Online Library
Key points The growth of new capillaries, angiogenesis, within skeletal muscle occurs only
after weeks of repeated aerobic exercise. Paradoxically, large increases in pro‐angiogenic …
after weeks of repeated aerobic exercise. Paradoxically, large increases in pro‐angiogenic …
Blunted muscle angiogenic training-response in COPD patients versus sedentary controls
The impaired skeletal muscle of chronic obstructive pulmonary disease (COPD) patients
reduces exercise capacity. Similar to the oxidative muscle fibres, the angio-adaptation of …
reduces exercise capacity. Similar to the oxidative muscle fibres, the angio-adaptation of …
Endothelial FoxO1 is an intrinsic regulator of thrombospondin 1 expression that restrains angiogenesis in ischemic muscle
E Roudier, M Milkiewicz, O Birot, D Slopack… - Angiogenesis, 2013 - Springer
Peripheral artery disease (PAD) is characterized by chronic muscle ischemia. Compensatory
angiogenesis is minimal within ischemic muscle despite an increase in angiogenic factors. …
angiogenesis is minimal within ischemic muscle despite an increase in angiogenic factors. …
[HTML][HTML] Inhibition of proliferation, migration and proteolysis contribute to corticosterone-mediated inhibition of angiogenesis
…, A Trifonova, ER Mandel, STK Liu, E Roudier… - 2012 - journals.plos.org
The angiostatic nature of pharmacological doses of glucocorticoid steroids is well known.
However, the consequences of pathophysiological elevation of endogenous glucocorticoids …
However, the consequences of pathophysiological elevation of endogenous glucocorticoids …