BACKGROUND: Increased oxidative stress and bronchial inflammation are important
mechanisms in the pathophysiology of COPD. AIM: To investigate whether treatment with the …

Objective To evaluate the effect of pulmonary rehabilitation (PR) on exercise performance
and quality of life in patients with chronic obstructive pulmonary disease (COPD) with different …

Background: Pulmonary rehabilitation is recognized as a core component of the management
of individuals with chronic respiratory disease. Since the 2006 American Thoracic Society (…

The objective of the study was to further unravel the prognostic significance of body weight
changes in patients with COPD. Two survival analyses were performed: (1) a retrospective …

Significant heterogeneity of clinical presentation and disease progression exists within
chronic obstructive pulmonary disease (COPD). Although FEV 1 inadequately describes this …

Smoking is one of the major lifestyle factors influencing the health of human beings. Life-long
cigarette smokers have a higher prevalence of common diseases such as atherosclerosis …

Background: Survival studies have consistently shown significantly greater mortality rates in
underweight and normal-weight patients with chronic obstructive pulmonary disease (COPD…

Background Acute exacerbations form a major component of the socioeconomic burden of
COPD. As yet, little information is available about the long-term outcome of patients who have …

Rationale: Comorbidities contribute to disease severity and mortality in patients with chronic
obstructive pulmonary disease (COPD). Comorbidities have been studied individually and …

… Spruit PhD a , Miriam TJ Groenen MSc a , Emiel FM Wouters PhD, MD a b , Daisy JA
Janssen PhD, MD a c … DJ Janssen, MA Spruit, JM Schols, EF Wouters …