The protective effect of farm milk consumption on childhood asthma and atopy: the GABRIELA study

…, J Weber, B Sozanska, H Danielewicz, E Horak… - Journal of Allergy and …, 2011 - Elsevier
BACKGROUND: Farm milk consumption has been identified as an exposure that might
contribute to the protective effect of farm life on childhood asthma and allergies. The mechanism …

Protection from childhood asthma and allergy in Alpine farm environments—the GABRIEL Advanced Studies

S Illi, M Depner, J Genuneit, E Horak, G Loss… - Journal of Allergy and …, 2012 - Elsevier
BACKGROUND: Studies on the association of farm environments with asthma and atopy
have repeatedly observed a protective effect of farming. However, no single specific farm-…

Mutations in CCNO result in congenital mucociliary clearance disorder with reduced generation of multiple motile cilia

…, T Zimmermann, C Koerner-Rettberg, E Horak… - Nature …, 2014 - nature.com
Using a whole-exome sequencing strategy, we identified recessive CCNO (encoding cyclin
O) mutations in 16 individuals suffering from chronic destructive lung disease due to …

The nexin-dynein regulatory complex subunit DRC1 is essential for motile cilia function in algae and humans

…, S Lindberg, U Stenram, B Carlén, E Horak… - Nature …, 2013 - nature.com
Primary ciliary dyskinesia (PCD) is characterized by dysfunction of respiratory cilia and
sperm flagella and random determination of visceral asymmetry. Here, we identify the DRC1 …

Bacterial microbiota of the upper respiratory tract and childhood asthma

…, AW Walker, LT Birzele, J Genuneit, E Horak… - Journal of Allergy and …, 2017 - Elsevier
Background Patients with asthma and healthy controls differ in bacterial colonization of the
respiratory tract. The upper airways have been shown to reflect colonization of the lower …

[HTML][HTML] Diagnosis and management of asthma–Statement on the 2015 GINA Guidelines

F Horak, D Doberer, E Eber, E Horak, W Pohl… - Wiener Klinische …, 2016 - Springer
This statement was written by a group of pulmonologists and pediatric pulmonologists belonging
to the corresponding professional associations ÖGP (Austrian Society for Pulmonology) …

[HTML][HTML] Meta-analysis identifies seven susceptibility loci involved in the atopic march

…, DS Postma, C Braun-Fahrländer, E Horak… - Nature …, 2015 - nature.com
Eczema often precedes the development of asthma in a disease course called the ‘atopic
march’. To unravel the genes underlying this characteristic pattern of allergic disease, we …

Gene-environment interaction for childhood asthma and exposure to farming in Central Europe

…, B Sozanska, A Boznanski, P Cullinan, E Horak… - Journal of allergy and …, 2011 - Elsevier
BACKGROUND: Asthma is a disease in which both genetic and environmental factors play
important roles. The farming environment has consistently been associated with protection …

Environmental and mucosal microbiota and their role in childhood asthma

…, S Kublik, C Bernau, GJ Loss, J Genuneit, E Horak… - Allergy, 2017 - Wiley Online Library
Background High microbial diversity in the environment has been associated with lower
asthma risk, particularly in children exposed to farming. It remains unclear whether this effect …

Longitudinal study of childhood wheezy bronchitis and asthma: outcome at age 42

E Horak, A Lanigan, M Roberts, L Welsh, J Wilson… - Bmj, 2003 - bmj.com
Longitudinal studies have reported that asthma in childhood has a good prognosis. However,
most of these studies have not taken into account the severity of childhood symptoms. 1 …