Anaerobic bacteria have been identified in abundance in the airways of cystic fibrosis (CF)
subjects. The impact their presence and abundance has on lung function and inflammation is …

Background Lung clearance index (LCI) has good clinimetric properties and an acceptable
feasibility profile as a surrogate end point in cystic fibrosis (CF). Although most studies to …

Age-related macular degeneration (AMD), is the leading cause of blind registration in the
Western World among individuals 65 years or older. Early AMD, a clinical state without overt …

BACKGROUND Alterations in the lung microbiota may drive disease development and
progression in patients with chronic respiratory diseases. Following lung transplantation (LTx), …

Lung disease is the main cause of morbidity and mortality in cystic fibrosis (CF), and involves
chronic infection and perturbed immune responses. Tissue damage is mediated mostly by …

Background Routine clinical culture detects a subset of the cystic fibrosis (CF) airways
microbiota based on culture-independent (molecular) methods. This study aimed to determine …

Background Whether there is any benefit in integrating culture-independent molecular analysis
of the lower airway microbiota of people with cystic fibrosis into clinical care is unclear. …

Introduction: Urinary biomarkers of pulmonary exacerbation in CF have not been as extensively
studied as blood, sputum and bronchial fluid. However, urine collection is less invasive …

Haptoglobin (Hp), a heme-Iron chelator, has different isoforms which are associated with
variable tendency toward infections: Hp 1-1, Hp 2-1, and Hp 2-2. Cystic fibrosis (CF) outcomes …

LCI is a robust measure of ventilation distribution in CF. There are no data demonstrating a
relationship between LCI and biomarkers of systemic inflammation during clinical stability. …