Theophylline restores histone deacetylase activity and steroid responses in COPD macrophages
Chronic obstructive pulmonary disease (COPD) is a common chronic inflammatory disease
of the lungs with little or no response to glucocorticoids and a high level of oxidative stress. …
of the lungs with little or no response to glucocorticoids and a high level of oxidative stress. …
Inhibition of PI3Kδ restores glucocorticoid function in smoking-induced airway inflammation in mice
…, CS Stevenson, P Casolari, E Jazrawi… - American journal of …, 2009 - atsjournals.org
Rationale: There is an increasing prevalence of reduced responsiveness to glucocorticoid
therapy in severe asthma and chronic obstructive pulmonary disease (COPD). The molecular …
therapy in severe asthma and chronic obstructive pulmonary disease (COPD). The molecular …
Histone acetylase and deacetylase activity in alveolar macrophages and blood mononocytes in asthma
Histone acetylation status is a key factor in the regulation of inflammatory gene transcription.
We investigated the activity of histone acetylases (HAT) and deacetylases (HDAC), and the …
We investigated the activity of histone acetylases (HAT) and deacetylases (HDAC), and the …
[HTML][HTML] The transcriptional co-activators CREB-binding protein (CBP) and p300 play a critical role in cardiac hypertrophy that is dependent on their histone …
RJ Gusterson, E Jazrawi, IM Adcock… - Journal of Biological …, 2003 - ASBMB
The CBP and p300 proteins are transcriptional co-activators that are involved in a variety of
transcriptional pathways in development and in response to specific signaling pathways. We …
transcriptional pathways in development and in response to specific signaling pathways. We …
Unbalanced oxidant-induced DNA damage and repair in COPD: a link towards lung cancer
Background Chronic obstructive pulmonary disease (COPD) is characterised by oxidative
stress and increased risk of lung carcinoma. Oxidative stress causes DNA damage which can …
stress and increased risk of lung carcinoma. Oxidative stress causes DNA damage which can …
Regulation of Th2 cytokine genes by p38 MAPK-mediated phosphorylation of GATA-3
K Maneechotesuwan, Y Xin, K Ito, E Jazrawi… - The Journal of …, 2007 - journals.aai.org
GATA-3 plays a critical role in allergic diseases by regulating the release of cytokines from
Th2 lymphocytes. However, the molecular mechanisms involved in the regulation of GATA-3 …
Th2 lymphocytes. However, the molecular mechanisms involved in the regulation of GATA-3 …
NF-κB and activator protein 1 response elements and the role of histone modifications in IL-1β-induced TGF-β1 gene transcription
KY Lee, K Ito, R Hayashi, EPI Jazrawi… - The Journal of …, 2006 - journals.aai.org
Abnormal expression of TGF-β1 is believed to play an important role in the pathogenesis of
a number of chronic inflammatory and immune lung diseases, including asthma, chronic …
a number of chronic inflammatory and immune lung diseases, including asthma, chronic …
Increased p21CIP1/WAF1 and B Cell Lymphoma Leukemia-xL Expression and Reduced Apoptosis in Alveolar Macrophages from Smokers
…, T Oates, I Chiselita, E Jazrawi… - American journal of …, 2002 - atsjournals.org
Alveolar macrophages (AMs) are the predominant defense cells in the airway, and their
numbers are increased in smokers and subjects with chronic obstructive pulmonary disease. …
numbers are increased in smokers and subjects with chronic obstructive pulmonary disease. …
[HTML][HTML] Suppression of GATA-3 nuclear import and phosphorylation: a novel mechanism of corticosteroid action in allergic disease
K Maneechotesuwan, X Yao, K Ito, E Jazrawi… - PLoS …, 2009 - journals.plos.org
Background GATA-3 plays a critical role in regulating the expression of the cytokines
interleukin (IL)-4, IL-5, and IL-13 from T helper-2 (Th2) cells and therefore is a key mediator of …
interleukin (IL)-4, IL-5, and IL-13 from T helper-2 (Th2) cells and therefore is a key mediator of …
[HTML][HTML] p65-activated histone acetyltransferase activity is repressed by glucocorticoids: mifepristone fails to recruit HDAC2 to the p65-HAT complex
Glucocorticoids acting through their specific receptor can either enhance or repress gene
transcription. Dexamethasone represses interleukin-1β-stimulated histone acetylation and …
transcription. Dexamethasone represses interleukin-1β-stimulated histone acetylation and …