Theophylline restores histone deacetylase activity and steroid responses in COPD macrophages

BG Cosio, L Tsaprouni, K Ito, E Jazrawi… - The Journal of …, 2004 - rupress.org
Chronic obstructive pulmonary disease (COPD) is a common chronic inflammatory disease
of the lungs with little or no response to glucocorticoids and a high level of oxidative stress. …

Inhibition of PI3Kδ restores glucocorticoid function in smoking-induced airway inflammation in mice

…, CS Stevenson, P Casolari, E Jazrawi… - American journal of …, 2009 - atsjournals.org
Rationale: There is an increasing prevalence of reduced responsiveness to glucocorticoid
therapy in severe asthma and chronic obstructive pulmonary disease (COPD). The molecular …

Histone acetylase and deacetylase activity in alveolar macrophages and blood mononocytes in asthma

BG Cosío, B Mann, K Ito, E Jazrawi… - American journal of …, 2004 - atsjournals.org
Histone acetylation status is a key factor in the regulation of inflammatory gene transcription.
We investigated the activity of histone acetylases (HAT) and deacetylases (HDAC), and the …

[HTML][HTML] The transcriptional co-activators CREB-binding protein (CBP) and p300 play a critical role in cardiac hypertrophy that is dependent on their histone …

RJ Gusterson, E Jazrawi, IM Adcock… - Journal of Biological …, 2003 - ASBMB
The CBP and p300 proteins are transcriptional co-activators that are involved in a variety of
transcriptional pathways in development and in response to specific signaling pathways. We …

Unbalanced oxidant-induced DNA damage and repair in COPD: a link towards lung cancer

G Caramori, IM Adcock, P Casolari, K Ito, E Jazrawi… - Thorax, 2011 - thorax.bmj.com
Background Chronic obstructive pulmonary disease (COPD) is characterised by oxidative
stress and increased risk of lung carcinoma. Oxidative stress causes DNA damage which can …

Regulation of Th2 cytokine genes by p38 MAPK-mediated phosphorylation of GATA-3

K Maneechotesuwan, Y Xin, K Ito, E Jazrawi… - The Journal of …, 2007 - journals.aai.org
GATA-3 plays a critical role in allergic diseases by regulating the release of cytokines from
Th2 lymphocytes. However, the molecular mechanisms involved in the regulation of GATA-3 …

NF-κB and activator protein 1 response elements and the role of histone modifications in IL-1β-induced TGF-β1 gene transcription

KY Lee, K Ito, R Hayashi, EPI Jazrawi… - The Journal of …, 2006 - journals.aai.org
Abnormal expression of TGF-β1 is believed to play an important role in the pathogenesis of
a number of chronic inflammatory and immune lung diseases, including asthma, chronic …

Increased p21CIP1/WAF1 and B Cell Lymphoma Leukemia-xL Expression and Reduced Apoptosis in Alveolar Macrophages from Smokers

…, T Oates, I Chiselita, E Jazrawi… - American journal of …, 2002 - atsjournals.org
Alveolar macrophages (AMs) are the predominant defense cells in the airway, and their
numbers are increased in smokers and subjects with chronic obstructive pulmonary disease. …

[HTML][HTML] Suppression of GATA-3 nuclear import and phosphorylation: a novel mechanism of corticosteroid action in allergic disease

K Maneechotesuwan, X Yao, K Ito, E Jazrawi… - PLoS …, 2009 - journals.plos.org
Background GATA-3 plays a critical role in regulating the expression of the cytokines
interleukin (IL)-4, IL-5, and IL-13 from T helper-2 (Th2) cells and therefore is a key mediator of …

[HTML][HTML] p65-activated histone acetyltransferase activity is repressed by glucocorticoids: mifepristone fails to recruit HDAC2 to the p65-HAT complex

K Ito, E Jazrawi, B Cosio, PJ Barnes… - Journal of Biological …, 2001 - ASBMB
Glucocorticoids acting through their specific receptor can either enhance or repress gene
transcription. Dexamethasone represses interleukin-1β-stimulated histone acetylation and …