The role of the glucocorticoid receptor (GR) in glucocorticoid physiology and during development
was investigated by generation of GR-deficient mice by gene targeting. GR -/- mice die …

The amiloride-sensitive epithelial sodium channel, ENaC, is a heteromultimeric protein
made up of three homologous subunits (α, β and γ) 1,2 . In vitro, assembly and expression of …

Salt taste in mammals can trigger two divergent behavioural responses. In general, concentrated
saline solutions elicit robust behavioural aversion, whereas low concentrations of NaCl …

Ca 2+ ions play a fundamental role in many cellular processes, and the extracellular concentration
of Ca 2+ is kept under strict control to allow the proper physiological functions to take …

Glut-2 is a low-affinity transporter present in the plasma membrane of pancreatic (β-cells,
hepatocytes and intestine and kidney absorptive epithelial cells of mice 1 . In β-cells, Glut-2 has …

▪ Abstract The epithelial sodium channel (ENaC) expressed in aldosterone-responsive epithelial
cells of the kidney and colon plays a critical role in the control of sodium balance, blood …

The cAMP response element binding protein (CREB) has been implicated as a key regulator
in the transcriptional control of many genes. To assess the functional importance of CREB …

To investigate the functional role of different α 1 -adrenergic receptor (α 1 -AR) subtypes in
vivo, we have applied a gene targeting approach to create a mouse model lacking the α 1b -…

Serine proteases are proteolytic enzymes that are involved in the regulation of various
physiological processes. We generated mice lacking the membrane-anchored channel-activating …

Regulation of sodium balance is a critical factor in the maintenance of euvolemia, and
dysregulation of renal sodium excretion results in disorders of altered intravascular volume, such …