The serpins (serine proteinase inhibitors) are a superfamily of proteins (350–500 amino
acids in size) that fold into a conserved structure and employ a unique suicide substrate-like …

In addition to their pivotal role in thrombosis and wound repair, platelets participate in
inflammatory responses. We investigated the role of platelets in the autoimmune disease …

The role of platelets in hemostasis is to produce a plug to arrest bleeding. During thrombocytopenia,
spontaneous bleeding is seen in some patients but not in others; the reason for this …

The Wiskott–Aldrich syndrome (WAS) is a primary immunodeficiency disorder caused by a
mutation in WAS protein (WASp) that results in defective actin polymerization. Although the …

Although compensatory islet hyperplasia in response to insulin resistance is a recognized
feature in diabetes, the factor(s) that promote β cell proliferation have been elusive. We …

… E. Remold‐O'Donnell provided mice, primers and helpful advice, analyzed data and contributed
to discussions. DD Wagner supervised the study, designed experiments, analyzed data …

A protein family, the ‘Ov‐serpins’ has been identified by comparing amino acid sequence,
protein characteristics and gene organization. The Ov‐serpins would not be recognized as a …

MNEI (monocyte/neutrophil elastase inhibitor) is a 42 kDa serpin superfamily protein
characterized initially as a fast-acting inhibitor of neutrophil elastase. Here we show that MNEI has …

Caspase-3–mediated spontaneous death in neutrophils is a prototype of programmed cell
death and is critical for modulating physiopathological inflammatory responses; however, the …

The Wiskott-Aldrich syndrome (WAS) is a disease of profound thrombocytopenia and severe
immune defects caused by an unidentified defective X chromosome gene. In this study, T …