Drug lag, recently discussed extensively in Japan, can be divided into two phases: clinical
development time and application review time. The former factor is still an important problem …

… The higher expression of MCT1 and LDHB was confirmed by western blotting (Figures S2E–S2H).
The analysis using chromatin immunoprecipitation sequencing (ChIP-seq) data in …

Bile acids play an essential role in the solubilization and absorption of dietary fat and lipid-soluble
vitamins. Bile acids also modulate the transcription of various genes for enzymes and …

Immune checkpoint blockade has provided a paradigm shift in cancer therapy, but the success
of this approach is very variable; therefore, biomarkers predictive of clinical efficacy are …

Background: Mikulicz’s disease (MD) has been considered as one manifestation of Sjögren’s
syndrome (SS). Recently, it has also been considered as an IgG 4 -related disorder. …

… Here, Sugiyama et al. find that these tumors have an immunosuppressive tumor … Two
pathological researchers (E. Sugiyama and GI) independently evaluated the stained …

On the basis of the fabrication of a CPU on glass as a digital circuit presented in B. Lee et al.
(2003) and T. Ikeda et al. (2004), as well as the fabrication of a flexible CPU using a TFT …

The mechanisms underlying alcoholic liver disease are not completely understood, but lipid
accumulation seems to be central to the cause of this disease. The peroxisome …

… Sugiyama has received speaking fees from AbbVie, Asahi Kasei Pharma, Astellas Pharma,
AYUMI, Bristol-Myers Squibb, Chugai Pharmaceutical, Eisai, Eli Lilly, Janssen, Pfizer, Sanofi…

Stevens–Johnson syndrome and toxic epidermal necrolysis (SJS/TEN) are severe, cutaneous
adverse drug reactions that are rare but life threatening. Genetic biomarkers for allopurinol…