Difficult/therapy-resistant asthma: the need for an integrated approach to define clinical phenotypes, evaluate risk factors, understand pathophysiology and find novel …
KF Chung, P Godard, E Adelroth… - European …, 1999 - Eur Respiratory Soc
A Task Force supported by the European Respiratory Society was set up in 1997 in order to
address the major issues relevant to difficult/therapy-resistant asthma. Although the group of …
address the major issues relevant to difficult/therapy-resistant asthma. Although the group of …
Effects of treatment on airway inflammation and thickening of basement membrane reticular collagen in asthma: a quantitative light and electron microscopic study
PK Jeffery, RW Godfrey, E Ädelroth… - American Review of …, 2012 - atsjournals.org
We have obtained airway mucosal biopsies by fiberoptic bronchoscopy for light and electron
microscopic analysis of three distinct airway levels of the left lung in three subject groups. …
microscopic analysis of three distinct airway levels of the left lung in three subject groups. …
Early thickening of the reticular basement membrane in children with difficult asthma
DNR Payne, AV Rogers, E Adelroth… - American journal of …, 2003 - atsjournals.org
Remodeling of the airway wall occurs in adults with asthma, and reticular basement membrane
(RBM) thickening is pathognomonic of the asthma process. To investigate whether RBM …
(RBM) thickening is pathognomonic of the asthma process. To investigate whether RBM …
Recombinant humanized mAb-E25, an anti-IgE mAb, in birch pollen–induced seasonal allergic rhinitis
E Ädelroth, S Rak, T Haahtela, G Aasand… - Journal of allergy and …, 2000 - Elsevier
Background: Allergic rhinitis is a common condition often requiring treatment. Objective: We
evaluated whether recombinant humanized (rhu)mAb-E25, a recombinant humanized …
evaluated whether recombinant humanized (rhu)mAb-E25, a recombinant humanized …
Myofibroblast involvement in the allergen-induced late response in mild atopic asthma.
MJ Gizycki, E Adelroth, AV Rogers… - American journal of …, 1997 - atsjournals.org
We undertook a detailed cellular and ultrastructural examination of bronchial biopsies from
seven allergic asthmatic patients and 10 nonasthmatic control subjects (five atopic and five …
seven allergic asthmatic patients and 10 nonasthmatic control subjects (five atopic and five …
Diesel exhaust enhances airway responsiveness in asthmatic subjects
…, JO Levin, T Sandström, E Ädelroth - European respiratory …, 2001 - Eur Respiratory Soc
Particulate matter (PM) pollution has been associated with negative health effects, including
exacerbations of asthma following exposure to PM peaks. The aim of the present study was …
exacerbations of asthma following exposure to PM peaks. The aim of the present study was …
Airway responsiveness to leukotrienes C4 and D4 and to methacholine in patients with asthma and normal controls
E Adelroth, MM Morris, FE Hargreave… - New England Journal …, 1986 - Mass Medical Soc
Leukotrienes C 4 and D 4 may serve as chemical mediators in asthma. Although patients
with asthma are known to be hyperresponsive to the bronchoconstrictive effects of histamine …
with asthma are known to be hyperresponsive to the bronchoconstrictive effects of histamine …
Airway inflammation following exposure to diesel exhaust: a study of time kinetics using induced sputum
…, JO Levin, T Sandstrom, E Adelroth - European …, 2000 - Eur Respiratory Soc
The adverse health effects of particulate matter pollution are of increasing concern. In a recent
bronchoscopic study in healthy volunteers, pronounced airway inflammation was detected …
bronchoscopic study in healthy volunteers, pronounced airway inflammation was detected …
Distinct immunohistochemical localization of IL-4 in human inflamed airway tissues. IL-4 is localized to eosinophils in vivo and is released by peripheral blood …
…, R Nonaka, K Woolley, E Adelroth… - … (Baltimore, Md.: 1950 …, 1995 - journals.aai.org
… Figure 1, E and F shows an almost complete absence of fluorescent cells in neutrophil
preparations. Only one cell shows fluorescence with FITC labeling (F, darkfield) that in the …
preparations. Only one cell shows fluorescence with FITC labeling (F, darkfield) that in the …
Reassessing the Th2 cytokine basis of asthma
PM O'Byrne, MD Inman, E Adelroth - Trends in pharmacological sciences, 2004 - cell.com
T helper (Th) 2 cytokines, particularly interleukin 4 (IL-4), IL-5 and IL-13, might be important
in the development of allergic asthma. Humanized monoclonal antibodies (hMAbs) against IL…
in the development of allergic asthma. Humanized monoclonal antibodies (hMAbs) against IL…