User profiles for Domenico Spina

Domenico Spina

Professor, Vrije Universiteit Brussel
Verified email at vub.be
Cited by 831

[HTML][HTML] Experimental design and analysis and their reporting: new guidance for publication in BJP

MJ Curtis, RA Bond, D Spina, A Ahluwalia… - British journal of …, 2015 - ncbi.nlm.nih.gov
This editorial is part of a series describing changes in the guidelines for authors making
submissions to the British Journal of Pharmacology (BJP)(McGrath and Curtis, 2015); McGrath …

Phosphodiesterase inhibitors

V Boswell‐Smith, D Spina… - British journal of …, 2006 - Wiley Online Library
Phosphodiesterases are a diverse family of enzymes that hydrolyse cyclic nucleotides and
thus play a key role in regulating intracellular levels of the second messengers cAMP and …

Platelet P-selectin is required for pulmonary eosinophil and lymphocyte recruitment in a murine model of allergic inflammation

SC Pitchford, S Momi, S Giannini, L Casali, D Spina… - Blood, 2005 - ashpublications.org
Platelets are necessary for lung leukocyte recruitment in a murine model of allergic
inflammation, and platelet–leukocyte aggregates are formed in circulating blood of patients with …

Platelets are essential for leukocyte recruitment in allergic inflammation

…, S Ciferri, MJ Rose, S Giannini, S Momi, D Spina… - Journal of allergy and …, 2003 - Elsevier
Background: The role of platelets in inflammation is recognized but poorly characterized, and
little is known of their interaction with leukocytes. However, platelet-leukocyte interactions …

A distinct role for transient receptor potential ankyrin 1, in addition to transient receptor potential vanilloid 1, in tumor necrosis factor α–induced inflammatory …

ES Fernandes, FA Russell, D Spina… - Arthritis & …, 2011 - Wiley Online Library
Objective To investigate the involvement of transient receptor potential ankyrin 1 (TRPA1) in
inflammatory hyperalgesia mediated by tumor necrosis factor α (TNFα) and joint …

Efficacy and safety of RPL554, a dual PDE3 and PDE4 inhibitor, in healthy volunteers and in patients with asthma or chronic obstructive pulmonary disease: findings …

…, M Cazzola, L Calzetta, D Singh, D Spina… - The lancet Respiratory …, 2013 - thelancet.com
Background Many patients with asthma or chronic obstructive pulmonary disease (COPD)
routinely receive a combination of an inhaled bronchodilator and anti-inflammatory …

Selective PDE inhibitors as novel treatments for respiratory diseases

CP Page, D Spina - Current opinion in pharmacology, 2012 - Elsevier
Phosphodiesterases (PDEs) are a family of enzymes which catalyse the metabolism of the
intracellular cyclic nucleotides, c-AMP and c-GMP that are expressed in a variety of cell types …

Platelets are necessary for airway wall remodeling in a murine model of chronic allergic inflammation

…, A Sousa, S Momi, P Gresele, D Spina… - Blood, 2004 - ashpublications.org
Asthma is associated with airway remodeling. Evidence of platelet recruitment to the lungs
of asthmatics after allergen exposure suggests platelets participate in various aspects of …

[HTML][HTML] Review of polynomial chaos-based methods for uncertainty quantification in modern integrated circuits

A Kaintura, T Dhaene, D Spina - Electronics, 2018 - mdpi.com
Advances in manufacturing process technology are key ensembles for the production of
integrated circuits in the sub-micrometer region. It is of paramount importance to assess the …

[HTML][HTML] Fucosylated chondroitin sulfates from the body wall of the sea cucumber Holothuria forskali: Conformation, selectin binding, and biological activity

…, Y Liu, W Chai, R Venkatasamy, D Spina… - Journal of Biological …, 2014 - ASBMB
Fucosylated chondroitin sulfate (fCS) extracted from the sea cucumber Holothuria forskali is
composed of the following repeating trisaccharide unit: →3)GalNAcβ4,6S(1→4) [FucαX(1→3…