User profiles for Domenico Spina
Domenico SpinaProfessor, Vrije Universiteit Brussel Verified email at vub.be Cited by 831 |
[HTML][HTML] Experimental design and analysis and their reporting: new guidance for publication in BJP
This editorial is part of a series describing changes in the guidelines for authors making
submissions to the British Journal of Pharmacology (BJP)(McGrath and Curtis, 2015); McGrath …
submissions to the British Journal of Pharmacology (BJP)(McGrath and Curtis, 2015); McGrath …
Phosphodiesterase inhibitors
V Boswell‐Smith, D Spina… - British journal of …, 2006 - Wiley Online Library
Phosphodiesterases are a diverse family of enzymes that hydrolyse cyclic nucleotides and
thus play a key role in regulating intracellular levels of the second messengers cAMP and …
thus play a key role in regulating intracellular levels of the second messengers cAMP and …
Platelet P-selectin is required for pulmonary eosinophil and lymphocyte recruitment in a murine model of allergic inflammation
SC Pitchford, S Momi, S Giannini, L Casali, D Spina… - Blood, 2005 - ashpublications.org
Platelets are necessary for lung leukocyte recruitment in a murine model of allergic
inflammation, and platelet–leukocyte aggregates are formed in circulating blood of patients with …
inflammation, and platelet–leukocyte aggregates are formed in circulating blood of patients with …
Platelets are essential for leukocyte recruitment in allergic inflammation
…, S Ciferri, MJ Rose, S Giannini, S Momi, D Spina… - Journal of allergy and …, 2003 - Elsevier
Background: The role of platelets in inflammation is recognized but poorly characterized, and
little is known of their interaction with leukocytes. However, platelet-leukocyte interactions …
little is known of their interaction with leukocytes. However, platelet-leukocyte interactions …
A distinct role for transient receptor potential ankyrin 1, in addition to transient receptor potential vanilloid 1, in tumor necrosis factor α–induced inflammatory …
ES Fernandes, FA Russell, D Spina… - Arthritis & …, 2011 - Wiley Online Library
Objective To investigate the involvement of transient receptor potential ankyrin 1 (TRPA1) in
inflammatory hyperalgesia mediated by tumor necrosis factor α (TNFα) and joint …
inflammatory hyperalgesia mediated by tumor necrosis factor α (TNFα) and joint …
Efficacy and safety of RPL554, a dual PDE3 and PDE4 inhibitor, in healthy volunteers and in patients with asthma or chronic obstructive pulmonary disease: findings …
…, M Cazzola, L Calzetta, D Singh, D Spina… - The lancet Respiratory …, 2013 - thelancet.com
Background Many patients with asthma or chronic obstructive pulmonary disease (COPD)
routinely receive a combination of an inhaled bronchodilator and anti-inflammatory …
routinely receive a combination of an inhaled bronchodilator and anti-inflammatory …
Selective PDE inhibitors as novel treatments for respiratory diseases
CP Page, D Spina - Current opinion in pharmacology, 2012 - Elsevier
Phosphodiesterases (PDEs) are a family of enzymes which catalyse the metabolism of the
intracellular cyclic nucleotides, c-AMP and c-GMP that are expressed in a variety of cell types …
intracellular cyclic nucleotides, c-AMP and c-GMP that are expressed in a variety of cell types …
Platelets are necessary for airway wall remodeling in a murine model of chronic allergic inflammation
Asthma is associated with airway remodeling. Evidence of platelet recruitment to the lungs
of asthmatics after allergen exposure suggests platelets participate in various aspects of …
of asthmatics after allergen exposure suggests platelets participate in various aspects of …
[HTML][HTML] Review of polynomial chaos-based methods for uncertainty quantification in modern integrated circuits
Advances in manufacturing process technology are key ensembles for the production of
integrated circuits in the sub-micrometer region. It is of paramount importance to assess the …
integrated circuits in the sub-micrometer region. It is of paramount importance to assess the …
[HTML][HTML] Fucosylated chondroitin sulfates from the body wall of the sea cucumber Holothuria forskali: Conformation, selectin binding, and biological activity
…, Y Liu, W Chai, R Venkatasamy, D Spina… - Journal of Biological …, 2014 - ASBMB
Fucosylated chondroitin sulfate (fCS) extracted from the sea cucumber Holothuria forskali is
composed of the following repeating trisaccharide unit: →3)GalNAcβ4,6S(1→4) [FucαX(1→3…
composed of the following repeating trisaccharide unit: →3)GalNAcβ4,6S(1→4) [FucαX(1→3…