[HTML][HTML] Expression of the T helper 17-associated cytokines IL-17A and IL-17F in asthma and COPD
C Doe, M Bafadhel, S Siddiqui, D Desai, V Mistry… - Chest, 2010 - Elsevier
Background Asthma and COPD are characterized by airway dysfunction and inflammation.
Neutrophilic airway inflammation is a common feature of COPD and is recognized in asthma, …
Neutrophilic airway inflammation is a common feature of COPD and is recognized in asthma, …
IgE Sensitization to Aspergillus fumigatus Is Associated with Reduced Lung Function in Asthma
…, RH Green, K Mutalithas, D Desai… - American journal of …, 2010 - atsjournals.org
Rationale: The importance of Aspergillus fumigatus sensitization and colonization of the
airways in patients with asthma is unclear. Objectives: To define the relationship between the …
airways in patients with asthma is unclear. Objectives: To define the relationship between the …
Elevated sputum interleukin-5 and submucosal eosinophilia in obese individuals with severe asthma
D Desai, C Newby, FA Symon, P Haldar… - American journal of …, 2013 - atsjournals.org
Rationale: The relationship between airway inflammation and obesity in severe asthma is
poorly understood. Objectives: We sought to determine the relationship between sputum …
poorly understood. Objectives: We sought to determine the relationship between sputum …
[HTML][HTML] Biological clustering supports both “Dutch” and “British” hypotheses of asthma and chronic obstructive pulmonary disease
Background Asthma and chronic obstructive pulmonary disease (COPD) are heterogeneous
diseases. Objective We sought to determine, in terms of their sputum cellular and mediator …
diseases. Objective We sought to determine, in terms of their sputum cellular and mediator …
Aspergillus fumigatus during stable state and exacerbations of COPD
…, S Mckenna, J Agbetile, A Fairs, D Desai… - European …, 2014 - Eur Respiratory Soc
Bacteria are often isolated in stable chronic obstructive pulmonary disease (COPD). Whether
fungi are also commonly present and associated with clinical and pathological features of …
fungi are also commonly present and associated with clinical and pathological features of …
[HTML][HTML] Biological exacerbation clusters demonstrate asthma and chronic obstructive pulmonary disease overlap with distinct mediator and microbiome profiles
MA Ghebre, PH Pang, S Diver, D Desai… - Journal of Allergy and …, 2018 - Elsevier
Background Exacerbations of asthma and chronic obstructive pulmonary disease (COPD)
are heterogeneous. Objective We sought to investigate the sputum cellular, mediator, and …
are heterogeneous. Objective We sought to investigate the sputum cellular, mediator, and …
[HTML][HTML] Rituximab versus intravenous cyclophosphamide in patients with connective tissue disease-associated interstitial lung disease in the UK (RECITAL): a double …
…, N Chaudhuri, F Chua, A Data, D Desai… - The Lancet …, 2023 - thelancet.com
Background Rituximab is often used as rescue therapy in interstitial lung disease (ILD)
associated with connective tissue disease (CTD), but has not been studied in clinical trials. This …
associated with connective tissue disease (CTD), but has not been studied in clinical trials. This …
Effectiveness of voriconazole in the treatment of Aspergillus fumigatus–associated asthma (EVITA3 study)
…, M Bourne, A Fairs, B Hargadon, D Desai… - Journal of allergy and …, 2014 - Elsevier
Background IgE sensitization to Aspergillus fumigatus and a positive sputum fungal culture
result are common in patients with refractory asthma. It is not clear whether these patients …
result are common in patients with refractory asthma. It is not clear whether these patients …
CCL 2 release by airway smooth muscle is increased in asthma and promotes fibrocyte migration
SR Singh, A Sutcliffe, D Kaur, S Gupta, D Desai… - Allergy, 2014 - Wiley Online Library
Background Asthma is characterized by variable airflow obstruction, airway inflammation,
airway hyper‐responsiveness and airway remodelling. Airway smooth muscle ( ASM ) …
airway hyper‐responsiveness and airway remodelling. Airway smooth muscle ( ASM ) …
Sputum microbiomic clustering in asthma and chronic obstructive pulmonary disease reveals a Haemophilus‐predominant subgroup
…, MA Ghebre, MY Ramsheh, M Bafadhel, D Desai… - Allergy, 2020 - Wiley Online Library
Background Airway ecology is altered in asthma and chronic obstructive pulmonary disease
(COPD). Anti‐microbial interventions might have benefit in subgroups of airway disease. …
(COPD). Anti‐microbial interventions might have benefit in subgroups of airway disease. …