User profiles for Deirdre Fitzgerald-Hughes

Deirdre Fitzgerald Hughes

Royal College of Surgeons in Ireland
Verified email at rcsi.com
Cited by 1521

[HTML][HTML] Memory Th1 Cells Are Protective in Invasive Staphylococcus aureus Infection

…, M Tavakol, CH Hearnden, D Fitzgerald-Hughes… - PLoS …, 2015 - journals.plos.org
Mechanisms of protective immunity to Staphylococcus aureus infection in humans remain
elusive. While the importance of cellular immunity has been shown in mice, T cell responses in …

[HTML][HTML] Effect of essential oils of Syzygium aromaticum and Cinnamomum zeylanicum and their major components on biofilm production in Staphylococcus aureus …

…, JL Gonçalves, MV Santos, D Fitzgerald-Hughes… - Journal of dairy …, 2015 - Elsevier
Bovine mastitis is an inflammation of the mammary glands of cows and causes significant
economic losses in dairy cattle. Staphylococcus aureus is one of the microorganisms most …

Eradication of Staphylococcus aureus Biofilm Infections Using Synthetic Antimicrobial Peptides

…, JP O'Gara, D Fitzgerald-Hughes… - The Journal of …, 2017 - academic.oup.com
Here, we demonstrate that antimicrobial peptides (AMPs) are an effective antibiofilm treatment
when applied as catheter lock solutions (CLSs) against S. aureus biofilm infections. The …

[HTML][HTML] Improving the management and treatment of diabetic foot infection: challenges and research opportunities

…, A Rajagopal, MT Pryce, D Fitzgerald Hughes - International Journal of …, 2023 - mdpi.com
Diabetic foot infection (DFI) management requires complex multidisciplinary care pathways
with off-loading, debridement and targeted antibiotic treatment central to positive clinical …

Air and surface contamination patterns of meticillin-resistant Staphylococcus aureus on eight acute hospital wards

…, N Walley, S McHugh, D Fitzgerald-Hughes… - Journal of Hospital …, 2014 - Elsevier
Background Meticillin-resistant Staphylococcus aureus (MRSA) can be recovered from
hospital air and from environmental surfaces. This poses a potential risk of transmission to …

Resistance to third-generation cephalosporins in human non-typhoidal Salmonella enterica isolates from England and Wales, 2010–12

…, E De Pinna, D Fitzgerald-Hughes… - Journal of …, 2014 - academic.oup.com
Objectives To identify the mechanism(s) underlying cefotaxime resistance in 118 of 21 641 (0.55%)
non-typhoidal Salmonella enterica isolates collected from humans throughout …

[HTML][HTML] A novel dual-functioning ruthenium (II)–arene complex of an anti-microbial ciprofloxacin derivative—Anti-proliferative and anti-microbial activity

Z Ude, I Romero-Canelón, B Twamley… - Journal of inorganic …, 2016 - Elsevier
7-(4-(Decanoyl)piperazin-1-yl)-ciprofloxacin, CipA, (1) which is an analogue of the antibiotic
ciprofloxacin, and its ruthenium(II) complex [Ru(η 6 -p-cymene)(CipA -H )Cl], (2) have been …

When are the hands of healthcare workers positive for meticillin-resistant Staphylococcus aureus?

…, A Dolan, O Sherlock, D Fitzgerald-Hughes… - Journal of Hospital …, 2010 - Elsevier
Hand hygiene is a key component in reducing infection. There are few reports on the
prevalance of meticillin-resistant Staphlococcus aureus (MRSA) on healthcare workers' (HCWs') …

Beyond conventional antibiotics for the future treatment of methicillin-resistant Staphylococcus aureus infections: two novel alternatives

D Fitzgerald-Hughes, M Devocelle… - FEMS Immunology & …, 2012 - academic.oup.com
The majority of antibiotics currently used to treat methicillin-resistant Staphylococus aureus (MRSA)
infections target bacterial cell wall synthesis or protein synthesis. Only daptomycin …

[HTML][HTML] Cytokine responses to Staphylococcus aureusbloodstream infection differ between patient cohorts that have different clinical courses of infection

…, CM Greene, H Humphreys, D Fitzgerald-Hughes - BMC infectious …, 2014 - Springer
Background The clinical course of Staphylococcus aureus bloodstream infection is unpredictable
and bacterial virulence, host immune response and patient characteristics are among …