Background As every healthcare intervention carries some risk of harm, clinical decision
making needs to be supported by a systematic assessment of the balance of benefit to harm. A …

Public debate over the safety of the trivalent measles, mumps and rubella (MMR) vaccine
and the drop in vaccination rates in several countries persists despite its almost universal use …

Objective To determine whether anecdotal reports of suspected adverse drug reactions are
valuable early warning signals. Design Systematic literature survey Data sources We …

Group therapy is a useful form of intervention for individuals with histories of extreme trauma.
This paper will discuss the relevance of group interventions with refugees and asylum …

Regulatory agencies grant product licences (marketing authorizations) for medicinal products
in the light of evidence that the balance between benefit and harm in the population is …

ML Rosenthal’s 1959 labeling of Robert Lowell’s Life Studies as “Confessional,” initiated a
debate about the literary value of autobiographical writing. At the center of this controversy …

Introduction: Indacaterol (IND) is an inhaled long-acting β2-agonist for the once daily treatment
of COPD, delivered via single-dose dry powder inhaler (Onbrez® Breezhaler®). Study …

Method: In an international, multicentre, clinical trial, COPD patients presenting to the
clinician with an acute exacerbation were asked to perform Spirometry.

From 1987 to 1988 the incidence of Lyme disease increased by nearly 50% in the US In
1988, 4,572 cases of Lyme disease were diagnosed in over 43 states with a total of 13,905 …

Pharmaceutical trials are reliant on accurate data to meet endpoints and eventual registration.
Using standardised equipment, well trained technicians 1 and over-readers 2 can …