Intratracheal administration of clinical-grade mesenchymal stem cell-derived extracellular vesicles reduces lung injury in a rat model of bronchopulmonary dysplasia

A Porzionato, P Zaramella, A Dedja… - … of Physiology-Lung …, 2019 - journals.physiology.org
Mesenchymal stem cells (MSCs) prevent the onset of bronchopulmonary dysplasia (BPD) in
animal models, an effect that seems to be mediated by their secreted extracellular vesicles (…

[HTML][HTML] Improvement of diaphragmatic performance through orthotopic application of decellularized extracellular matrix patch

…, L Urbani, ME Alvarez-Fallas, C Franzin, A Dedja… - Biomaterials, 2016 - Elsevier
Muscle tissue engineering can provide support to large congenital skeletal muscle defects
using scaffolds able to allow cell migration, proliferation and differentiation. Acellular …

Intratracheal administration of mesenchymal stem cell-derived extracellular vesicles reduces lung injuries in a chronic rat model of bronchopulmonary dysplasia

A Porzionato, P Zaramella, A Dedja… - … of Physiology-Lung …, 2021 - journals.physiology.org
Early therapeutic effect of intratracheally (IT)-administered extracellular vesicles secreted by
mesenchymal stem cells (MSC-EVs) has been demonstrated in a rat model of …

Human amniotic fluid stem cells protect rat lungs exposed to moderate hyperoxia

D Grisafi, M Pozzobon, A Dedja, V Vanzo… - Pediatric …, 2013 - Wiley Online Library
Background Treatment of bronchopulmonary dysplasia (BPD) remains as yet an unmet clinical
need and recently stem cells have been proposed as a therapeutic tool in animal models. …

Ureteral stenosis in HDAF pig‐to‐primate renal xenotransplantation: a phenomenon related to immunological events?

…, F Calabrese, R Cadrobbi, A Dedja… - American Journal of …, 2004 - Wiley Online Library
The aim of this study was to analyze the incidence of ureteral stenosis in a life‐supporting
human decay‐accelerating factor (hDAF) transgenic pig‐to‐cynomolgus monkey kidney …

[HTML][HTML] Porcine decellularized diaphragm hydrogel: a new option for skeletal muscle malformations

D Boso, E Carraro, E Maghin, S Todros, A Dedja… - Biomedicines, 2021 - mdpi.com
Hydrogels are biomaterials that, thanks to their unique hydrophilic and biomimetic characteristics,
are used to support cell growth and attachment and promote tissue regeneration. The …

Cardiac interstitial cells express GATA4 and control dedifferentiation and cell cycle re-entry of adult cardiomyocytes

T Zaglia, A Dedja, C Candiotto, E Cozzi… - Journal of molecular and …, 2009 - Elsevier
Interstitial cells of the adult rat heart were characterized with respect to i) expression of cardiac
markers of commitment and differentiation, ii) myogenic potential in vitro and iii) ability to …

[HTML][HTML] Allogenic tissue-specific decellularized scaffolds promote long-term muscle innervation and functional recovery in a surgical diaphragmatic hernia model

C Trevisan, E Maghin, A Dedja, P Caccin, N de Cesare… - Acta Biomaterialia, 2019 - Elsevier
Congenital diaphragmatic hernia (CDH) is a neonatal defect in which the diaphragm muscle
does not develop properly, thereby raising abdominal organs into the thoracic cavity and …

[HTML][HTML] Decellularized diaphragmatic muscle drives a constructive angiogenic response in vivo

…, M Piccoli, C Franzin, A Sgrò, A Dedja… - International journal of …, 2018 - mdpi.com
Skeletal muscle tissue engineering (TE) aims to efficiently repair large congenital and
acquired defects. Biological acellular scaffolds are considered a good tool for TE, as …

L-citrulline Prevents Alveolar and Vascular Derangement in a Rat Model of Moderate Hyperoxia-induced Lung Injury

D Grisafi, E Tassone, A Dedja, B Oselladore, V Masola… - Lung, 2012 - Springer
Background Moderate normobaric hyperoxia causes alveolar and vascular lung derangement
in the newborn rat. Endogenous nitric oxide (NO), which promotes lung growth, is …