The β-Agonist Lung Injury Trial (BALTI) a randomized placebo-controlled clinical trial

GD Perkins, DF McAuley, DR Thickett… - American journal of …, 2006 - atsjournals.org
Rationale: Experimental data suggest that manipulation of alveolar fluid clearance with β-agonists
can accelerate the resolution of alveolar edema and improve survival. Objective: To …

[HTML][HTML] Vitamin D deficiency contributes directly to the acute respiratory distress syndrome (ARDS)

…, DM Sansom, AR Martineau, GD Perkins, DR Thickett - Thorax, 2015 - thorax.bmj.com
Rationale Vitamin D deficiency has been implicated as a pathogenic factor in sepsis and
intensive therapy unit mortality but has not been assessed as a risk factor for acute respiratory …

Cigarette smoke exposure and alveolar macrophages: mechanisms for lung disease

ST Lugg, A Scott, D Parekh, B Naidu, DR Thickett - Thorax, 2022 - thorax.bmj.com
Cigarette smoking is the leading cause of preventable death worldwide. It causes chronic
lung disease and predisposes individuals to acute lung injury and pulmonary infection. …

Epithelial–mesenchymal transition in lung development and disease: does it exist and is it important?

D Bartis, N Mise, RY Mahida, O Eickelberg, DR Thickett - Thorax, 2014 - thorax.bmj.com
Epithelial–mesenchymal transition (EMT) is a process when epithelial cells gradually transform
into mesenchymal-like cells losing their epithelial functionality and characteristics. EMT …

Simvastatin decreases lipopolysaccharide-induced pulmonary inflammation in healthy volunteers

…, TR Craig, V Brown, DR Thickett… - American journal of …, 2009 - atsjournals.org
Rationale: Simvastatin inhibits inflammatory responses in vitro and in murine models of lung
inflammation in vivo. As simvastatin modulates a number of the underlying processes …

Vascular endothelial growth factor may contribute to increased vascular permeability in acute respiratory distress syndrome

DR Thickett, L Armstrong, SJ Christie… - American journal of …, 2001 - atsjournals.org
The development of noncardiogenic pulmonary edema is a characteristic feature of acute
respiratory distress syndrome (ARDS). We hypothesized that vascular endothelial growth …

Outcome of hospitalization for COVID-19 in patients with interstitial lung disease. An international multicenter study

…, GM Stella, H Stone, S Sturney, D Thickett… - American journal of …, 2020 - atsjournals.org
Rationale: The impact of coronavirus disease (COVID-19) on patients with interstitial lung
disease (ILD) has not been established. Objectives: To assess outcomes in patients with ILD …

[HTML][HTML] Pro-inflammatory effects of e-cigarette vapour condensate on human alveolar macrophages

…, D Parekh, R Foronjy, E Sapey, B Naidu, DR Thickett - Thorax, 2018 - thorax.bmj.com
Objective Vaping may increase the cytotoxic effects of e-cigarette liquid (ECL). We
compared the effect of unvaped ECL to e-cigarette vapour condensate (ECVC) on alveolar …

Long-term impact of developing a postoperative pulmonary complication after lung surgery

…, MS Kalkat, RS Steyn, PB Rajesh, DR Thickett… - Thorax, 2016 - thorax.bmj.com
Introduction Postoperative pulmonary complications (PPC) such as atelectasis and
pneumonia are common following lung resection. PPCs have a significant clinical impact on …

Residual lung abnormalities after COVID-19 hospitalization: interim analysis of the UKILD post–COVID-19 study

…, LG Spencer, S Stanel, DR Thickett… - American journal of …, 2023 - atsjournals.org
Rationale: Shared symptoms and genetic architecture between coronavirus disease (COVID-19)
and lung fibrosis suggest severe acute respiratory syndrome coronavirus 2 (SARS-CoV-…