Prevalence and Impact of Bronchiectasis in α1-Antitrypsin Deficiency

DG Parr, PG Guest, JH Reynolds… - American journal of …, 2007 - atsjournals.org
… Correspondence and requests for reprints should be addressed to David G. Parr, MD,
Department of Respiratory Medicine, University Hospitals of Coventry and Warwickshire, Coventry …

European Respiratory Society statement: diagnosis and treatment of pulmonary disease in α1-antitrypsin deficiency

…, R Mahadeva, NG McElvaney, D Parr… - European …, 2017 - Eur Respiratory Soc
α 1 -antitrypsin deficiency (AATD) is the most common hereditary disorder in adults. It is
associated with an increased risk of developing pulmonary emphysema and liver disease. The …

Pattern of emphysema distribution in α1-antitrypsin deficiency influences lung function impairment

DG Parr, BC Stoel, J Stolk… - American journal of …, 2004 - atsjournals.org
FEV 1 is fundamental to the diagnosis and staging of chronic obstructive pulmonary disease.
In emphysema, airflow obstruction usually coexists with impairment of gas exchange, but …

[HTML][HTML] Therapeutic efficacy of alpha-1 antitrypsin augmentation therapy on the loss of lung tissue: an integrated analysis of 2 randomised clinical trials using …

RA Stockley, DG Parr, E Piitulainen, J Stolk… - Respiratory …, 2010 - Springer
Background Two randomised, double-blind, placebo-controlled trials have investigated the
efficacy of IV alpha-1 antitrypsin (AAT) augmentation therapy on emphysema progression …

[HTML][HTML] Quantitative computed tomography–derived clusters: Redefining airway remodeling in asthmatic patients

…, RP Marshall, D Subramanian, D Parr… - Journal of allergy and …, 2014 - Elsevier
Background Asthma heterogeneity is multidimensional and requires additional tools to unravel
its complexity. Computed tomography (CT)–assessed proximal airway remodeling and …

[HTML][HTML] Progression parameters for emphysema: a clinical investigation

J Stolk, H Putter, EM Bakker, SB Shaker, DG Parr… - Respiratory …, 2007 - Elsevier
In patients with airflow limitation caused by cigarette smoking, lung density measured by
computed tomography is strongly correlated with quantitative pathology scores of emphysema, …

[HTML][HTML] Exploring the optimum approach to the use of CT densitometry in a randomised placebo-controlled study of augmentation therapy in alpha 1-antitrypsin …

DG Parr, A Dirksen, E Piitulainen, C Deng… - Respiratory …, 2009 - Springer
Background Computed tomography (CT) lung densitometry has been demonstrated to be
the most sensitive and specific outcome measure for the assessment of emphysema-modifying …

Assessment of pulmonary neutrophilic inflammation in emphysema by quantitative positron emission tomography

…, R Edgar, N Quraishi, RA Stockley, DG Parr - American journal of …, 2012 - atsjournals.org
… Correspondence and requests for reprints should be addressed to David G. Parr, MA,
MBBS, MD, Clinical Director, Cardio-Thoracic Group, Department of Respiratory Medicine, …

[HTML][HTML] The prevalence of obstructive sleep apnoea in women with polycystic ovary syndrome: a systematic review and meta-analysis

…, S Johnson, PDH Wall, A Metcalfe, DG Parr… - Sleep and …, 2020 - Springer
Background Obesity is a common risk factor for polycystic ovary syndrome (PCOS) and
obstructive sleep apnoea (OSA). Both PCOS and OSA are associated with increased risk of type …

Influence of calibration on densitometric studies of emphysema progression using computed tomography

DG Parr, BC Stoel, J Stolk, PG Nightingale… - American journal of …, 2004 - atsjournals.org
The fundamental importance of calibration for any measuring device is indisputable, but
computed tomography (CT) calibration in longitudinal lung densitometry studies is largely …