User profiles for David Lechuga-Ballesteros
David Lechuga-BallesterosResearch Fellow, AstraZeneca Pharmaceuticals, Ltd Verified email at astrazeneca.com Cited by 4598 |
Particle formation in spray drying
R Vehring, WR Foss, D Lechuga-Ballesteros - Journal of aerosol science, 2007 - Elsevier
Theoretical and experimental investigations of the particle formation process during spray
drying are presented. A novel experimental method allows observation of individual, free …
drying are presented. A novel experimental method allows observation of individual, free …
Improvement of the dispersibility of spray-dried budesonide powders using leucine in an ethanol–water cosolvent system
…, S Hoe, H Sharif, DP Miller, D Lechuga-Ballesteros… - Powder technology, 2013 - Elsevier
A new approach for enhancing the dispersibility of respirable powders containing poorly
soluble pharmaceutical actives is demonstrated. Budesonide was spray-dried with leucine from …
soluble pharmaceutical actives is demonstrated. Budesonide was spray-dried with leucine from …
Cosuspensions of microcrystals and engineered microparticles for uniform and efficient delivery of respiratory therapeutics from pressurized metered dose inhalers
R Vehring, D Lechuga-Ballesteros, V Joshi, B Noga… - Langmuir, 2012 - ACS Publications
Engineered porous phospholipid microparticles with aerodynamic diameters in the
respirable range of 1–2 μm were cosuspended in 1,1,1,2-tetrafluoroethane, a propellant, with …
respirable range of 1–2 μm were cosuspended in 1,1,1,2-tetrafluoroethane, a propellant, with …
Prediction of the onset of crystallization of amorphous sucrose below the calorimetric glass transition temperature from correlations with mobility
The objective of the present work is to determine if crystallization onset observed for an
amorphous solid correlate with relaxation time at temperatures above and below the calorimetric …
amorphous solid correlate with relaxation time at temperatures above and below the calorimetric …
On the particle formation of leucine in spray drying of inhalable microparticles
…, M Nicholas, S Gracin, D Lechuga-Ballesteros… - International Journal of …, 2021 - Elsevier
The particle formation of L-leucine, a dispersibility-enhancing amino acid used in the spray
drying of inhalable pharmaceutical aerosols, was extensively studied using three …
drying of inhalable pharmaceutical aerosols, was extensively studied using three …
Rapid assessment of the structural relaxation behavior of amorphous pharmaceutical solids: effect of residual water on molecular mobility
DP Miller, D Lechuga-Ballesteros - Pharmaceutical research, 2006 - Springer
Purpose Use RH-perfusion microcalorimetry and other analytical techniques to measure the
interactions between water vapor and amorphous pharmaceutical solids; use these …
interactions between water vapor and amorphous pharmaceutical solids; use these …
Trileucine improves aerosol performance and stability of spray‐dried powders for inhalation
D Lechuga‐Ballesteros, C Charan, CLM Stults… - Journal of …, 2008 - Elsevier
For particles to be useful medicinal aerosols, not only their aerodynamic diameter has to be
on the order of a few micrometers but also they have to be chemically and physically stable. …
on the order of a few micrometers but also they have to be chemically and physically stable. …
Heat-stable measles vaccine produced by spray drying
…, D Chen, DD Kristensen, D Lechuga-Ballesteros… - Vaccine, 2010 - Elsevier
A combination of unique stabilizers and mild spray drying process conditions was employed
to produce heat-stable measles vaccine powder. Live attenuated measles vaccine from …
to produce heat-stable measles vaccine powder. Live attenuated measles vaccine from …
Phase transition and heterogeneous/epitaxial nucleation of hydrated and anhydrous theophylline crystals
N Rodríguez-Hornedo, D Lechuga-Ballesteros… - International journal of …, 1992 - Elsevier
Theophylline crystallizes in the anhydrous or monohydrate form. The solubility of the anhydrous
form exceeds the solubility of the monohydrate form below 60C. The anhydrous: hydrate …
form exceeds the solubility of the monohydrate form below 60C. The anhydrous: hydrate …
Pharmaceutical liquid crystals: the relevance of partially ordered systems
…, DB Bennett, D Lechuga-Ballesteros - Journal of …, 2005 - Elsevier
Pharmaceutical solids have generally been characterized as either three-dimensional
crystals or amorphous solids based on X-ray powder diffraction and modulated temperature …
crystals or amorphous solids based on X-ray powder diffraction and modulated temperature …