Background. Invasive fungal diseases are important causes of morbidity and mortality. Clarity
and uniformity in defining these infections are important factors in improving the quality of …

Although fungal infections contribute substantially to human morbidity and mortality, the
impact of these diseases on human health is not widely appreciated. Moreover, despite the …

Fungal diseases kill more than 1.5 million and affect over a billion people. However, they
are still a neglected topic by public health authorities even though most deaths from fungal …

Recurrent vulvovaginal candidiasis is a debilitating, long-term condition that can severely
affect the quality of life of affected women. No estimates of the global prevalence or lifetime …

Background Voriconazole is a broad-spectrum triazole that is active against aspergillus
species. We conducted a randomized trial to compare voriconazole with amphotericin B for …

Since the first description of invasive aspergillosis as an opportunistic infection in 1953 [1],
there has been a substantial increase in the number of cases documented at autopsy in all …

The echinocandins are large lipopeptide molecules that are inhibitors of β-(1,3)-glucan
synthesis, an action that damages fungal cell walls. In vitro and in vivo, the echinocandins are …

The aspergilli comprise a diverse group of filamentous fungi spanning over 200 million
years of evolution. Here we report the genome sequence of the model organism Aspergillus …

The genome of Aspergillus oryzae, a fungus important for the production of traditional
fermented foods and beverages in Japan, has been sequenced. The ability to secrete large …

Fungi infect billions of people every year, yet their contribution to the global burden of
disease is largely unrecognized. Most are “relatively” minor infections, but millions contract …