Protein arginine methylation is a novel posttranslational modification regulating a diversity
of cellular processes, including protein-protein interaction, signal transduction, or histone …

Protein arginine methylation is catalyzed by a family of enzymes called protein arginine
methyltransferases (PRMTs). Three forms of methylarginine have been identified in eukaryotes: …

Asymmetric dimethylarginine (ADMA) is an endogenous inhibitor of nitric oxide synthesis.
ADMA is generated by catabolism of proteins containing methylated arginine residues, and its …

Mast cell (MC) accumulation has been demonstrated in the lungs of idiopathic pulmonary
fibrosis (IPF) patients. Mediators released from MCs may regulate tissue remodeling processes…

Rationale: Activation of the coagulation cascade has been demonstrated in pulmonary
fibrosis. In addition to its procoagulant function, various coagulation proteases exhibit cellular …

Lung fibrosis is characterized by increased deposition of ECM, especially collagens, and
enhanced proliferation of fibroblasts. l-arginine is a key precursor of nitric oxide, asymmetric …

Pirfenidone is an antifibrotic drug, recently approved for the treatment of patients with idiopathic
pulmonary fibrosis (IPF). Although pirfenidone exhibits anti‐inflammatory, antioxidant, …

Cell surface-associated proteolysis mediated by plasmin (PLA) is an essential feature of
wound healing, angiogenesis and cell invasion, processes that are dysregulated in cancer …

Idiopathic pulmonary fibrosis (IPF) is a progressive, dysregulated response to alveolar injury
that culminates in compromised lung function from excess extracellular matrix production. …

Protein arginine methylation is a novel posttranslational modification that plays a pivotal role
in a variety of intracellular events, such as signal transduction, protein-protein interaction …